■全身状况较差的食道癌患者只需接受放疗,但结果往往不能令人满意。这项研究的目的是阐明食管癌单纯放疗的近期结果。
■接受50Gy或以上放疗而未接受化疗的患者进行回顾性分析。终点是总生存期(OS),疾病特异性生存率(DSS),本地控制(LC),无进展生存期(PFS)。使用Kaplan-Meier方法绘制生存曲线,和预测因子使用Cox比例风险模型进行分析。
■纳入69例患者。中位随访期为17.9个月。5年OS,DSS,LC,PFS率为33.2%,49.8%,46.2%,和16.8%,分别。在多元Cox比例风险模型中,临床分期是OS的重要预测指标(风险比[HR]:4.42,95%置信区间[CI]:1.80-11.17,p=0.001),DSS(HR:2.08,95%CI:1.43-3.12,p=0.0001),LC(HR:1.86,95%CI:1.28-2.74,p=0.001),和PFS(HR:1.65,95%CI:1.25-2.18,p=0.0004)。辐射剂量是LC的显著预测因子(HR:0.87,95%CI:0.78-0.97,p=0.018),肿瘤位置是PFS的显著预测因子(HR:1.55,95%CI:1.10-2.19,p=0.018)。在亚组分析中,5年OS,DSS,LC,第一阶段的PFS率为60.0%,80.0%,71.9%,和46.1%,分别。
■舞台,辐射剂量,和肿瘤位置是预后的重要预测因子。I期食管癌患者可通过单纯放疗治愈。
UNASSIGNED: Patients with esophageal cancer who are in a poor general condition receive radiotherapy alone, but outcomes are often unsatisfactory. The aim of this study was to clarify recent outcomes of radiotherapy alone for esophageal cancer.
UNASSIGNED: Patients who underwent 50 Gy or more of radiotherapy without chemotherapy were retrospectively reviewed. Endpoints were overall survival (OS), disease-specific survival (DSS), local control (LC), and progression-free survival (PFS). Survival curves were drawn using the Kaplan-Meier method, and predictors were analyzed using the Cox proportional hazards model.
UNASSIGNED: Sixty-nine patients were included. The median follow-up period was 17.9 months. The 5-year OS, DSS, LC, and PFS rates were 33.2%, 49.8%, 46.2%, and 16.8%, respectively. In the multivariate Cox proportional hazard model, clinical stage was a significant predictor for OS (hazard ratio [HR]: 4.42, 95% confidence interval [CI]: 1.80-11.17, p = 0.001), DSS (HR: 2.08, 95% CI: 1.43-3.12, p = 0.0001), LC (HR: 1.86, 95% CI: 1.28-2.74, p = 0.001), and PFS (HR: 1.65, 95% CI: 1.25-2.18, p = 0.0004). Radiation dose was a significant predictor for LC (HR: 0.87, 95% CI: 0.78-0.97, p = 0.018) and tumor location was a significant predictor for PFS (HR: 1.55, 95% CI: 1.10-2.19, p = 0.018). In subgroup analysis, the 5-year OS, DSS, LC, and PFS rates for stage I were 60.0%, 80.0%, 71.9%, and 46.1%, respectively.
UNASSIGNED: Stage, radiation dose, and tumor location are significant predictors for outcomes. Patients with stage I esophageal cancer can be cured by radiotherapy alone.