echolocating蝙蝠是所有哺乳动物中最具社交性和嗓音的。鉴于这些动物的相对肥大的边缘和听觉神经结构以及听到MRI梯度噪声的能力降低,这些动物是听觉社交交流功能MRI(fMRI)研究的理想对象。然而,没有与社会认知相关的静息状态网络(例如,默认的类似模式的网络或DMLN)已经在蝙蝠中被识别出来,因为很少,如果有的话,功能磁共振成像研究在肩科目。这里,我们从9只轻度麻醉的浅矛鼻蝙蝠(毛竹变色)获得了7特斯拉的功能MRI数据。我们应用独立成分分析(ICA)来揭示静息状态网络和测量的神经活动,该活动由跨越该物种的超声波听觉范围(20至130kHz)的噪声波纹(开:10ms;关:10ms)引起。静息状态网络遍布听觉,顶叶,和枕骨皮质,以及海马体,小脑,基底神经节,和听觉脑干。两个中线网络形成了明显的DMLN。此外,我们发现了四个主要的听觉/顶叶皮层网络,其中两个是左偏侧的,两个是右偏侧的。已知四个听觉/顶叶皮层网络内的区域响应于社交呼叫。连同听觉脑干,这四个皮层网络中的区域对超声噪声波动做出了反应。迭代分析显示一致,左端之间的显著功能连接,但不对,听觉/顶叶皮层网络和DMLN节点,尤其是最前扣带皮质.因此,一个涉及社会认知的静息状态网络在左边显示出更多的分布式功能连通性,相对于权利,在这种高度社交和声乐的物种中,听觉和交流的半球皮质基质。
Echolocating bats are among the most social and vocal of all mammals. These animals are ideal subjects for functional MRI (fMRI) studies of auditory social communication given their relatively hypertrophic limbic and auditory neural structures and their reduced ability to hear MRI gradient noise. Yet, no resting-state networks relevant to social cognition (e.g., default mode-like networks or DMLNs) have been identified in bats since there are few, if any, fMRI studies in the chiropteran order. Here, we acquired fMRI data at 7 Tesla from nine lightly anesthetized pale spear-nosed bats (Phyllostomus discolor). We applied independent components analysis (ICA) to reveal resting-state networks and measured neural activity elicited by noise ripples (on: 10 ms; off: 10 ms) that span this species\' ultrasonic hearing range (20 to 130 kHz). Resting-state networks pervaded auditory, parietal, and occipital cortices, along with the hippocampus, cerebellum, basal ganglia, and auditory brainstem. Two midline networks formed an apparent DMLN. Additionally, we found four predominantly auditory/parietal cortical networks, of which two were left-lateralized and two right-lateralized. Regions within four auditory/parietal cortical networks are known to respond to social calls. Along with the auditory brainstem, regions within these four cortical networks responded to ultrasonic noise ripples. Iterative analyses revealed consistent, significant functional connectivity between the left, but not right, auditory/parietal cortical networks and DMLN nodes, especially the anterior-most cingulate cortex. Thus, a resting-state network implicated in social cognition displays more distributed functional connectivity across left, relative to right, hemispheric cortical substrates of audition and communication in this highly social and vocal species.