■口腔鳞状细胞癌(OSCC)是影响口腔的全球性恶性上皮性肿瘤。钙粘蛋白,作为粘附分子,参与细胞间的相互作用。我们旨在研究两种钙黏着蛋白多态性对伊朗东南部OSCC风险的影响。
■在本病例对照研究中,94人(47例OSCC病例和47例对照),提到口腔病理学系,牙科学院,Zahedan医科大学,伊朗被包括在内。钙黏着蛋白单核苷酸多态性CDH1(rs16260)和CDH2(rs11564299)通过四扩增难治性突变系统-PCR技术进行基因分型。
■N-cadherin基因分型表明,AA,AG,AG+GG占78.7%,17%,21.3%对66%,29.7%,34%的病例和对照组,分别。AG基因型在对照组比病例更常见(OR=0.47,95%CI:0.17-1.29,p=0.14)。G等位基因在对照组(19.1%)比病例组(12.8%)更普遍(OR=0.61,95%CI:0.27-1.36,p=0.23)。在E-cadherin中,AC,AA,AC+AA基因型频率为17%,12.8%,案例为29.8%,案例为8.5%,8.5%,对照组为17%。等位基因A在病例组比对照组更常见(OR=1.84,95%CI:0.84-4.03,p=0.12)。此外,AA和CC,在所有组织病理学分级中,显性基因型分别在CDH2和CDH1中常见,并且在OSCC不同组织病理学等级和钙黏着蛋白基因型之间没有观察到静态显着关联(N-钙黏着蛋白中的p=0.39,E-cadherin中p=0.74)。
■我们的结果表明,在伊朗东南部人群中,CDH1和CDH2基因多态性与OSCC风险之间缺乏关联。
UNASSIGNED: Oral squamous cell carcinoma (OSCC) is a global malignant epithelial neoplasm affecting the oral cavity. Cadherins, as an adhesion molecule, are involved in cell-cell interaction. We aim to study the effect of two cadherin polymorphisms on OSCC risk in southeast of Iran.
UNASSIGNED: In this case-control study, 94 individuals (47 OSCC cases and 47 controls), that referred to the Department of Oral Pathology, Faculty of Dentistry, Zahedan University of Medical Sciences, Iran were included. Cadherin single nucleotide polymorphisms CDH1 (rs16260) and CDH2 (rs11564299) were genotyped by the tetra-Amplification Refractory Mutation System-PCR technique.
UNASSIGNED: N-cadherin genotyping showed that the AA, AG, and AG + GG were presented 78.7%, 17%, 21.3% versus 66%, 29.7%, 34% in the cases and the control group, respectively. AG genotype was more common in control than case (OR = 0.47, 95% CI: 0.17-1.29, p = 0.14). G allele was more prevalent in control (19.1%) than the case group (12.8%) (OR = 0.61, 95% CI: 0.27-1.36, p = 0.23). In E-cadherin, AC, AA, and AC + AA genotypes frequency were 17%, 12.8%, and 29.8% in case versus 8.5%, 8.5%, and 17% in the control group. Allele A was more common in the case than the control group (OR = 1.84, 95% CI: 0.84-4.03, p = 0.12). Also, AA and CC, the codominant genotypes were common in CDH2 and CDH1 respectively in all histopathological grades, and no statically significant association was observed between OSCC different histopathological grades and cadherin genotypes (p = 0.39 in N-cadherin, p = 0.74 in E-cadherin).
UNASSIGNED: Our results showed a lack of association between CDH1 and CDH2 gene polymorphisms with OSCC risk in a population of Southeastern of Iran.