Diverticulitis, Colonic

憩室炎,结肠
  • 文章类型: Journal Article
    目的:机器人辅助手术是一种选择,进行结直肠手术的快速发展技术。此单中心分析的主要目的是比较选择性腹腔镜和机器人乙状结肠切除术治疗憩室疾病的手术创伤程度和费用。
    方法:从我们的前瞻性临床数据库中进行回顾性分析,以确定2016年1月至2020年12月在我们的三级转诊机构接受择期微创左侧结肠憩室切除术的所有年龄≥18岁的患者。
    结果:总计,83例(女31例,男52例)乙状结肠憩室炎患者行选择性微创乙状结肠切除术,其中42例接受了传统腹腔镜手术(LS)和41例机器人辅助手术(RS)。机器人辅助组(4,03mg/dL)术前和术后的平均C反应蛋白差异显着低于腹腔镜组(7.32mg/dL)(p=0.030)。同样,机器人的血红蛋白差异显著较低(p=0.039).LS组术后第一次排便发生在平均2.19天后,RS组的平均1.63天后(p=0.011)。总体费用的概述显示,机器人方法的每次手术和术后住院时间的总成本显着降低。6058€vs.6142€(p=0.014),不包括两个系统的购置和维护成本。
    结论:机器人结肠切除术治疗憩室病具有成本效益,与传统腹腔镜相比,术中创伤减少,术后C反应蛋白和血红蛋白漂移显著降低。
    OBJECTIVE: Robotic assisted surgery is an alternative, fast evolving technique for performing colorectal surgery. The primary aim of this single center analysis is to compare elective laparoscopic and robotic sigmoid colectomies for diverticular disease on the extent of operative trauma and the costs.
    METHODS: Retrospective analysis from our prospective clinical database to identify all consecutive patients aged ≥ 18 years who underwent elective minimally invasive left sided colectomy for diverticular disease from January 2016 until December 2020 at our tertiary referral institution.
    RESULTS: In total, 83 patients (31 female and 52 male) with sigmoid diverticulitis underwent elective minimally invasive sigmoid colectomy, of which 42 underwent conventional laparoscopic surgery (LS) and 41 robotic assisted surgery (RS). The mean C-reactive protein difference between the preoperative and postoperative value was significantly lower in the robotic assisted group (4,03 mg/dL) than in the laparoscopic group (7.32 mg/dL) (p = 0.030). Similarly, the robotic´s hemoglobin difference was significantly lower (p = 0.039). The first postoperative bowel movement in the LS group occurred after a mean of 2.19 days, later than after a mean of 1.63 days in the RS group (p = 0.011). An overview of overall charge revealed significantly lower total costs per operation and postoperative hospital stay for the robotic approach, 6058 € vs. 6142 € (p = 0,014) not including the acquisition and maintenance costs for both systems.
    CONCLUSIONS: Robotic colon resection for diverticular disease is cost-effective and delivers reduced intraoperative trauma with significantly lower postoperative C-reactive protein and hemoglobin drift compared to conventional laparoscopy.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
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  • 文章类型: Case Reports
    该病例突出了乙状结肠憩室炎的罕见表现,伴有腹膜后穿孔并发脓肿,椎体骨髓炎和急性下肢缺血。一名40岁高龄的男子因左下肢急性缺血被送往急诊科。他心动过速伴有白细胞增多症,平淡无奇的腹部检查和无动于衷,麻木和瘫痪的左下肢。影像学显示乙状结肠增厚,与髂血管相邻的脓肿和左动脉闭塞。脓肿在L5-S1椎骨处与先前的脊柱前路腰椎椎间融合术(ALIF)硬件接触。病人被紧急送往手术室进行取栓,血栓切除术和筋膜切开术。他开始使用抗生素,后来接受了骨髓炎清创术的手术引流。复杂憩室炎的非手术治疗失败,需要开腹乙状结肠切除术。一年后,他没有症状,结肠造口术被逆转。
    This case highlights a rare presentation of diverticulitis of the sigmoid colon with perforation into the retroperitoneum complicated by abscess, vertebral osteomyelitis and acute lower extremity ischemia. A late 40-year-old man presented to an emergency department with acute ischemia of his left lower extremity. He was tachycardic with a leucocytosis, an unremarkable abdominal exam and a pulseless, insensate and paralysed left lower extremity. Imaging revealed sigmoid thickening, an abscess adjacent to iliac vasculature and occlusion of the left popliteal artery. The abscess came in contact with prior spine anterior lumbar interbody fusion (ALIF) hardware at L5-S1 vertebrae. The patient was taken urgently to the operating room for embolectomy, thrombectomy and fasciotomy. He was started on antibiotics and later underwent operative drainage with debridement for osteomyelitis. Non-operative management of the complicated diverticulitis failed, necessitating open sigmoidectomy with colostomy. 1 year later, he was symptom-free and the colostomy was reversed.
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  • 文章类型: Case Reports
    憩室疾病是住院的主要原因,尤其是老年人。尽管憩室病及其并发症主要影响结肠,小肠憩室的形成,最常见的是十二指肠,在文献中有很好的特点。尽管小肠憩室通常无症状,顺便诊断出来,十二指肠壶腹周围憩室的并发症是Lemmel综合征。Lemmel综合征是一种极其罕见的疾病,其中壶腹周围十二指肠憩室,最常见的是没有憩室炎,由于肿块效应和相关并发症,包括急性胆管炎和胰腺炎,导致胆总管阻塞。这里,我们提出第一个案例,根据我们的知识,十二指肠壶腹周围憩室炎并发Lemmel综合征合并结肠憩室炎合并结肠膀胱瘘。我们的病例和文献综述强调,Lemmel综合征可以存在或不存在阻塞性黄疸的建议,如果早期发现,通常可以保守治疗。除了在紧急并发症的背景下。
    Diverticular disease is a major cause of hospitalizations, especially in the elderly. Although diverticulosis and its complications predominately affect the colon, the formation of diverticula in the small intestine, most commonly in the duodenum, is well characterized in the literature. Although small bowel diverticula are typically asymptomatic, and diagnosed incidentally, a complication of periampullary duodenal diverticulum is Lemmel syndrome. Lemmel syndrome is an extremely rare condition whereby periampullary duodenal diverticula, most commonly without diverticulitis, leads to obstruction of the common bile duct due to mass effect and associated complications including acute cholangitis and pancreatitis. Here, we present the first case, to our knowledge, of periampullary duodenal diverticulitis complicated by Lemmel syndrome with concomitant colonic diverticulitis with colovesical fistula. Our case and literature review emphasizes that Lemmel syndrome can present with or without suggestions of obstructive jaundice and can most often be managed conservatively if caught early, except in the setting of emergent complications.
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  • 文章类型: Journal Article
    背景:腹腔镜灌洗(LPL)已被建议用于治疗非生殖道穿孔憩室炎。在这项观察性研究中,在前瞻性试验之外研究了瑞典憩室病的外科治疗.
    方法:这项基于人群的研究使用国家患者登记册来确定瑞典所有因憩室疾病而紧急入院的患者,根据2014年7月至2020年12月的ICD代码定义。人口统计,评估手术程序和结果.此外,自1997年以来的登记数据被检索以评估合并症,以前的腹部手术,和以前因憩室疾病入院。
    结果:在47294例急诊住院患者中,2035例接受LPL(427例)或乙状结肠切除术(SR,1608例)用于憩室疾病。平均随访30.8个月。选择LPL的患者更年轻,与SR组相比,健康且以前的憩室疾病腹部手术次数较少(P<0.01)。LPL与术后住院时间较短相关(平均9.4天对14.9天,P<0.001)和更低的30天死亡率(3.5%对8.7%,P<0.001)。除第一年外,SR组比LPL组更常见与关节病相关的后续手术(P<0.001)。在研究期间,LPL的死亡率较低(分层HR0.70,95%c.i.0.53-0.92,P=0.023)。
    结论:腹腔镜灌洗是一种安全的替代乙状结肠切除术的选择,适用于临床判断需要手术的患者。
    憩室炎是大肠小袋内的炎症。很少,憩室炎可导致肠穿孔,引起腹膜炎。传统上,它是通过切除发炎的肠和造口来治疗的。已经提出了更温和的治疗方法,其中用盐水腹腔镜冲洗腹部并引流(腹腔镜灌洗)。本研究旨在检查瑞典腹腔镜灌洗的结果。我们的发现支持在没有或仅有轻微腹部手术史的年轻和健康患者中使用这种方法。
    BACKGROUND: Laparoscopic lavage (LPL) has been suggested for treatment of non-feculent perforated diverticulitis. In this observational study, the surgical treatment of diverticular disease in Sweden outside prospective trials was investigated.
    METHODS: This population-based study used the National Patient Register to identify all patients in Sweden with emergency admissions for diverticular disease, as defined by ICD codes from July 2014 to December 2020. Demographics, surgical procedures and outcomes were assessed. In addition, register data since 1997 were retrieved to assess co-morbidities, previous abdominal surgeries, and previous admissions for diverticular disease.
    RESULTS: Among 47 294 patients with emergency hospital admission, 2035 underwent LPL (427 patients) or sigmoid resection (SR, 1608 patients) for diverticular disease. The mean follow-up was 30.8 months. Patients selected for LPL were younger, healthier and with less previous abdominal surgery for diverticular disease than those in the SR group (P < 0.01). LPL was associated with shorter postoperative hospital stay (mean 9.4 versus 14.9 days, P < 0.001) and lower 30-day mortality (3.5% versus 8.7%, P < 0.001). Diverticular disease-associated subsequent surgery was more common in the SR group than the LPL group except during the first year (P < 0.001). LPL had a lower mortality rate during the study period (stratified HR 0.70, 95% c.i. 0.53-0.92, P = 0.023).
    CONCLUSIONS: Laparoscopic lavage constitutes a safe alternative to sigmoid resection for selected patients judged clinically to require surgery.
    Diverticulitis is inflammation in pouches of the large bowel. Rarely, diverticulitis can lead to a bowel perforation causing peritonitis. Traditionally, it was treated by resection of the inflamed bowel with a stoma. A milder treatment has been proposed in which the abdomen is rinsed with saline laparoscopically and drained (laparoscopic lavage). This study aimed to examine the outcomes of laparoscopic lavage in Sweden. Our findings support the use of this method in younger and healthier patients with a history of no or only minor previous abdominal surgery.
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  • 文章类型: Journal Article
    在西方国家,憩室病和憩室炎仍然是常见的诊断,发病率继续上升。憩室炎每年约占急性护理医院入院人数的三分之一,由于对风险分层和疾病进展的自然史的认识提高,更多的患者被作为门诊患者接受治疗。因此,全面了解疾病的病因,结合计算机断层扫描结果和患者表现,可以帮助决定适当的治疗。
    Diverticulosis and diverticulitis remain common diagnoses in western countries, and the incidence continues to rise. Diverticulitis accounts for roughly one-third of admissions to acute care hospitals annually, with even more patients being treated as outpatients due to improved understanding of risk stratification and the natural history of disease progression. Thus, having a thorough understanding of the etiology of the disease in conjunction with computed tomography findings and patient presentation can help dictate the appropriate treatment.
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  • 文章类型: Journal Article
    背景:具有腔外空气的急性憩室炎构成了一种异质性疾病,其治疗存在争议。这项研究的目的是报告腔外空气保守治疗憩室炎的失败率,并报告保守治疗失败的危险因素。
    方法:从2015年至2021年在三级转诊中心接受急性憩室炎并腔外空气的机构审查委员会批准的数据库中进行了一项回顾性研究。包括所有治疗急性憩室炎并有覆盖性穿孔(无腹腔脓肿)的患者。主要终点是药物治疗失败,定义为入院后30天内需要进行计划外手术或经皮引流。
    结果:93例患者(61%为男性,平均年龄57±17岁)被回顾性纳入。10例患者保守治疗失败(11%)。这些患者年龄明显大于50岁(n=9/10,90%与n=47/83,57%,p=0.007),与心血管疾病相关(n=6/10,60%与n=10/83,12%,p=0.002),美国麻醉医师协会(ASA)得分为3-4分(n=4/7,57%对6/33,18%,p=0.05),抗凝和抗血小板(n=6/10,60%与n=11/83,13%,p=0.04)和类固醇或免疫抑制治疗(n=3/10,30%对5/83,6%,p=0.04),并伴有远处的气腹位置(n=7/10,70%对n=14/83,17%,p=0.001)与成功保守治疗的患者相比。在多变量分析中,仅远处气腹是失败的独立危险因素(优势比(OR)6.5,95%置信区间(CI)[2-21],p=0.002)。
    结论:用抗生素保守治疗急性憩室炎并腔外空气是安全的,成功率为89%。远端气腹患者应仔细监测。
    BACKGROUND: Acute diverticulitis with extraluminal air constitutes a heterogeneous condition whose management is controversial. The aims of this study are to report the failure rate of conservative treatment for diverticulitis with extraluminal air and to report risk factors of conservative treatment failure.
    METHODS: A retrospective study was performed from an institutional review board-approved database of patients admitted with acute diverticulitis with extraluminal air from 2015 to 2021 at a tertiary referral center. All patients managed for acute diverticulitis with covered perforation (without intraabdominal abscess) were included. The primary endpoint was failure of medical treatment, defined as a need for unplanned surgery or percutaneous drainage within 30 days after admission.
    RESULTS: Ninety-three patients (61% male, mean age 57 ± 17 years) were retrospectively included. Ten patients had failure of conservative treatment (11%). These patients were significantly older than 50 years (n = 9/10, 90% versus n = 47/83, 57%, p = 0.007), associated with cardiovascular disease (n = 6/10, 60% versus n = 10/83, 12%, p = 0.002), American Society of Anesthesiologists (ASA) score of 3-4 (n = 4/7, 57% versus 6/33, 18%, p = 0.05), under anticoagulant and antiplatelet (n = 6/10, 60% versus n = 11/83, 13%, p = 0.04) and steroid or immunosuppressive therapy (n = 3/10, 30% versus 5/83, 6%, p = 0.04), and with distant pneumoperitoneum location (n = 7/10, 70% versus n = 14/83, 17%, p = 0.001) compared with those with successful conservative treatment. On multivariate analysis, only distant pneumoperitoneum was an independent risk factor of failure (odds ratio (OR) 6.5, 95% confidence interval (CI) [2-21], p = 0.002).
    CONCLUSIONS: Conservative treatment with antibiotics for acute diverticulitis with extraluminal air is safe with a success rate of 89%. Patients with distant pneumoperitoneum should be carefully monitored.
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  • 文章类型: Journal Article
    背景:急性复杂性憩室炎给个体患者和卫生保健系统带来了巨大的负担。很大一部分案件需要紧急行动。在Hartmann术式和原发性吻合术与分流回肠造口术之间的选择仍然存在争议。
    方法:使用2012年至2020年的美国外科医生协会国家手术质量改进计划患者用户文件数据,确定了接受Hartmann手术和初次吻合术合并分流回肠造口术的非选择性乙状结肠切除术治疗复杂性憩室炎的患者。主要不良事件,30天死亡率,围手术期并发症,手术持续时间,再操作,并评估了30天的再入院时间.
    结果:在16,921例中,6.3%的人接受了原发性吻合术和分流回肠造口术,呈现上升趋势,从2012年的5.3%上升到2020年的8.4%。原发性吻合术伴分流回肠造口术患者,与哈特曼的手术相比,具有相似的人口统计学特征和较少的严重合并症。初次吻合术合并分流回肠造口术的主要不良事件发生率较低(24.6%vs29.3%,P=.001)。风险调整后,与Hartmann's手术相比,初次吻合术合并分流回肠造口术的主要不良事件和30日死亡率风险相似.虽然有较低的几率呼吸(调整的比值比0.61,95%置信区间0.45-0.83)和感染(调整的比值比0.78,95%置信区间0.66-0.93)并发症,与Hartmann's手术相比,初次吻合术合并分流回肠造口术的手术时间延长36分钟,再入院30天的几率增加(校正比值比1.30,95%置信区间1.07-1.57).
    结论:在急性复杂憩室炎中,与Hartmann手术相比,初次吻合术合并分流回肠造口术显示出相当的主要不良事件几率,同时减轻了感染和呼吸道并发症的风险。然而,初次吻合术合并分流回肠造口术与更长的手术时间和更大的30天再入院几率相关.不断发展的指南和增加的原发性吻合术与转移回肠造口术的使用表明了有利于原发性吻合术的转变。尤其是复杂憩室炎。有必要对手术方法和患者预后的差异进行进一步研究,以优化急性憩室炎的护理途径。
    BACKGROUND: Acute complicated diverticulitis poses a substantial burden to individual patients and the health care system. A significant proportion of the cases necessitate emergency operations. The choice between Hartmann\'s procedure and primary anastomosis with diverting loop ileostomy remains controversial.
    METHODS: Using American College of Surgeons National Surgical Quality Improvement Program patient user file data from 2012 to 2020, patients undergoing Hartmann\'s procedure and primary anastomosis with diverting loop ileostomy for nonelective sigmoidectomy for complicated diverticulitis were identified. Major adverse events, 30-day mortality, perioperative complications, operative duration, reoperation, and 30-day readmissions were assessed.
    RESULTS: Of 16,921 cases, 6.3% underwent primary anastomosis with diverting loop ileostomy, showing a rising trend from 5.3% in 2012 to 8.4% in 2020. Primary anastomosis with diverting loop ileostomy patients, compared to Hartmann\'s procedure, had similar demographics and fewer severe comorbidities. Primary anastomosis with diverting loop ileostomy exhibited lower rates of major adverse events (24.6% vs 29.3%, P = .001). After risk adjustment, primary anastomosis with diverting loop ileostomy had similar risks of major adverse events and 30-day mortality compared to Hartmann\'s procedure. While having lower odds of respiratory (adjusted odds ratio 0.61, 95% confidence interval 0.45-0.83) and infectious (adjusted odds ratio 0.78, 95% confidence interval 0.66-0.93) complications, primary anastomosis with diverting loop ileostomy was associated with a 36-minute increment in operative duration and increased odds of 30-day readmission (adjusted odds ratio 1.30, 95% confidence interval 1.07-1.57) compared to Hartmann\'s procedure.
    CONCLUSIONS: Primary anastomosis with diverting loop ileostomy displayed comparable odds of major adverse events compared to Hartmann\'s procedure in acute complicated diverticulitis while mitigating infectious and respiratory complication risks. However, primary anastomosis with diverting loop ileostomy was associated with longer operative times and greater odds of 30-day readmission. Evolving guidelines and increasing primary anastomosis with diverting loop ileostomy use suggest a shift favoring primary anastomosis, especially in complicated diverticulitis. Future investigation of disparities in surgical approaches and patient outcomes is warranted to optimize acute diverticulitis care pathways.
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  • 文章类型: Journal Article
    背景:这项多中心病例对照研究旨在确定CT扫描HincheyIb-IIb和WSESIb-IIa憩室脓肿患者非手术治疗失败的危险因素。
    方法:本研究包括一组首次出现CT诊断憩室脓肿的成年患者,所有患者均接受了初始非手术治疗,包括单独使用抗生素或联合经皮引流.根据非手术治疗的结果对队列进行分层,特别确定需要紧急手术干预的患者为治疗失败的患者。采用多变量logistic回归分析确定非手术治疗失败的独立危险因素。
    结果:116例(27.04%)患者保守治疗失败。CT扫描Hinchey分类IIb(aOR2.54,95CI1.61;4.01,P<0.01),吸烟(aOR2.01,95CI1.24;3.25,P<0.01),脓肿内存在气泡(aOR1.59,95CI1.00;2.52,P=0.04)是失败的独立预测因子.在脓肿>5cm的患者亚组中,经皮穿刺引流与非手术治疗失败或成功的风险无关(aOR2.78,95CI-0.66;3.70,P=0.23).
    结论:对于憩室脓肿,非手术治疗通常是有效的。吸烟作为治疗失败的独立危险因素的作用强调了在憩室疾病管理中需要有针对性的行为干预措施。IIbHinchey憩室炎患者,尤其是年轻的吸烟者,由于治疗失败和脓毒症进展的风险增加,需要警惕监测。对图像引导经皮引流的疗效的进一步研究应包括随机,多中心研究侧重于同质患者群体。
    BACKGROUND: This multicentre case-control study aimed to identify risk factors associated with non-operative treatment failure for patients with CT scan Hinchey Ib-IIb and WSES Ib-IIa diverticular abscesses.
    METHODS: This study included a cohort of adult patients experiencing their first episode of CT-diagnosed diverticular abscess, all of whom underwent initial non-operative treatment comprising either antibiotics alone or in combination with percutaneous drainage. The cohort was stratified based on the outcome of non-operative treatment, specifically identifying those who required emergency surgical intervention as cases of treatment failure. Multivariable logistic regression analysis to identify independent risk factors associated with the failure of non-operative treatment was employed.
    RESULTS: Failure of conservative treatment occurred for 116 patients (27.04%). CT scan Hinchey classification IIb (aOR 2.54, 95%CI 1.61;4.01, P < 0.01), tobacco smoking (aOR 2.01, 95%CI 1.24;3.25, P < 0.01), and presence of air bubbles inside the abscess (aOR 1.59, 95%CI 1.00;2.52, P = 0.04) were independent predictors of failure. In the subgroup of patients with abscesses > 5 cm, percutaneous drainage was not associated with the risk of failure or success of the non-operative treatment (aOR 2.78, 95%CI - 0.66;3.70, P = 0.23).
    CONCLUSIONS: Non-operative treatment is generally effective for diverticular abscesses. Tobacco smoking\'s role as an independent risk factor for treatment failure underscores the need for targeted behavioural interventions in diverticular disease management. IIb Hinchey diverticulitis patients, particularly young smokers, require vigilant monitoring due to increased risks of treatment failure and septic progression. Further research into the efficacy of image-guided percutaneous drainage should involve randomized, multicentre studies focussing on homogeneous patient groups.
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