Diverticulitis, Colonic

憩室炎,结肠
  • 文章类型: Journal Article
    目的:机器人辅助手术是一种选择,进行结直肠手术的快速发展技术。此单中心分析的主要目的是比较选择性腹腔镜和机器人乙状结肠切除术治疗憩室疾病的手术创伤程度和费用。
    方法:从我们的前瞻性临床数据库中进行回顾性分析,以确定2016年1月至2020年12月在我们的三级转诊机构接受择期微创左侧结肠憩室切除术的所有年龄≥18岁的患者。
    结果:总计,83例(女31例,男52例)乙状结肠憩室炎患者行选择性微创乙状结肠切除术,其中42例接受了传统腹腔镜手术(LS)和41例机器人辅助手术(RS)。机器人辅助组(4,03mg/dL)术前和术后的平均C反应蛋白差异显着低于腹腔镜组(7.32mg/dL)(p=0.030)。同样,机器人的血红蛋白差异显著较低(p=0.039).LS组术后第一次排便发生在平均2.19天后,RS组的平均1.63天后(p=0.011)。总体费用的概述显示,机器人方法的每次手术和术后住院时间的总成本显着降低。6058€vs.6142€(p=0.014),不包括两个系统的购置和维护成本。
    结论:机器人结肠切除术治疗憩室病具有成本效益,与传统腹腔镜相比,术中创伤减少,术后C反应蛋白和血红蛋白漂移显著降低。
    OBJECTIVE: Robotic assisted surgery is an alternative, fast evolving technique for performing colorectal surgery. The primary aim of this single center analysis is to compare elective laparoscopic and robotic sigmoid colectomies for diverticular disease on the extent of operative trauma and the costs.
    METHODS: Retrospective analysis from our prospective clinical database to identify all consecutive patients aged ≥ 18 years who underwent elective minimally invasive left sided colectomy for diverticular disease from January 2016 until December 2020 at our tertiary referral institution.
    RESULTS: In total, 83 patients (31 female and 52 male) with sigmoid diverticulitis underwent elective minimally invasive sigmoid colectomy, of which 42 underwent conventional laparoscopic surgery (LS) and 41 robotic assisted surgery (RS). The mean C-reactive protein difference between the preoperative and postoperative value was significantly lower in the robotic assisted group (4,03 mg/dL) than in the laparoscopic group (7.32 mg/dL) (p = 0.030). Similarly, the robotic´s hemoglobin difference was significantly lower (p = 0.039). The first postoperative bowel movement in the LS group occurred after a mean of 2.19 days, later than after a mean of 1.63 days in the RS group (p = 0.011). An overview of overall charge revealed significantly lower total costs per operation and postoperative hospital stay for the robotic approach, 6058 € vs. 6142 € (p = 0,014) not including the acquisition and maintenance costs for both systems.
    CONCLUSIONS: Robotic colon resection for diverticular disease is cost-effective and delivers reduced intraoperative trauma with significantly lower postoperative C-reactive protein and hemoglobin drift compared to conventional laparoscopy.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
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  • 文章类型: Case Reports
    憩室疾病是住院的主要原因,尤其是老年人。尽管憩室病及其并发症主要影响结肠,小肠憩室的形成,最常见的是十二指肠,在文献中有很好的特点。尽管小肠憩室通常无症状,顺便诊断出来,十二指肠壶腹周围憩室的并发症是Lemmel综合征。Lemmel综合征是一种极其罕见的疾病,其中壶腹周围十二指肠憩室,最常见的是没有憩室炎,由于肿块效应和相关并发症,包括急性胆管炎和胰腺炎,导致胆总管阻塞。这里,我们提出第一个案例,根据我们的知识,十二指肠壶腹周围憩室炎并发Lemmel综合征合并结肠憩室炎合并结肠膀胱瘘。我们的病例和文献综述强调,Lemmel综合征可以存在或不存在阻塞性黄疸的建议,如果早期发现,通常可以保守治疗。除了在紧急并发症的背景下。
    Diverticular disease is a major cause of hospitalizations, especially in the elderly. Although diverticulosis and its complications predominately affect the colon, the formation of diverticula in the small intestine, most commonly in the duodenum, is well characterized in the literature. Although small bowel diverticula are typically asymptomatic, and diagnosed incidentally, a complication of periampullary duodenal diverticulum is Lemmel syndrome. Lemmel syndrome is an extremely rare condition whereby periampullary duodenal diverticula, most commonly without diverticulitis, leads to obstruction of the common bile duct due to mass effect and associated complications including acute cholangitis and pancreatitis. Here, we present the first case, to our knowledge, of periampullary duodenal diverticulitis complicated by Lemmel syndrome with concomitant colonic diverticulitis with colovesical fistula. Our case and literature review emphasizes that Lemmel syndrome can present with or without suggestions of obstructive jaundice and can most often be managed conservatively if caught early, except in the setting of emergent complications.
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  • 文章类型: Journal Article
    背景:腹腔镜灌洗(LPL)已被建议用于治疗非生殖道穿孔憩室炎。在这项观察性研究中,在前瞻性试验之外研究了瑞典憩室病的外科治疗.
    方法:这项基于人群的研究使用国家患者登记册来确定瑞典所有因憩室疾病而紧急入院的患者,根据2014年7月至2020年12月的ICD代码定义。人口统计,评估手术程序和结果.此外,自1997年以来的登记数据被检索以评估合并症,以前的腹部手术,和以前因憩室疾病入院。
    结果:在47294例急诊住院患者中,2035例接受LPL(427例)或乙状结肠切除术(SR,1608例)用于憩室疾病。平均随访30.8个月。选择LPL的患者更年轻,与SR组相比,健康且以前的憩室疾病腹部手术次数较少(P<0.01)。LPL与术后住院时间较短相关(平均9.4天对14.9天,P<0.001)和更低的30天死亡率(3.5%对8.7%,P<0.001)。除第一年外,SR组比LPL组更常见与关节病相关的后续手术(P<0.001)。在研究期间,LPL的死亡率较低(分层HR0.70,95%c.i.0.53-0.92,P=0.023)。
    结论:腹腔镜灌洗是一种安全的替代乙状结肠切除术的选择,适用于临床判断需要手术的患者。
    憩室炎是大肠小袋内的炎症。很少,憩室炎可导致肠穿孔,引起腹膜炎。传统上,它是通过切除发炎的肠和造口来治疗的。已经提出了更温和的治疗方法,其中用盐水腹腔镜冲洗腹部并引流(腹腔镜灌洗)。本研究旨在检查瑞典腹腔镜灌洗的结果。我们的发现支持在没有或仅有轻微腹部手术史的年轻和健康患者中使用这种方法。
    BACKGROUND: Laparoscopic lavage (LPL) has been suggested for treatment of non-feculent perforated diverticulitis. In this observational study, the surgical treatment of diverticular disease in Sweden outside prospective trials was investigated.
    METHODS: This population-based study used the National Patient Register to identify all patients in Sweden with emergency admissions for diverticular disease, as defined by ICD codes from July 2014 to December 2020. Demographics, surgical procedures and outcomes were assessed. In addition, register data since 1997 were retrieved to assess co-morbidities, previous abdominal surgeries, and previous admissions for diverticular disease.
    RESULTS: Among 47 294 patients with emergency hospital admission, 2035 underwent LPL (427 patients) or sigmoid resection (SR, 1608 patients) for diverticular disease. The mean follow-up was 30.8 months. Patients selected for LPL were younger, healthier and with less previous abdominal surgery for diverticular disease than those in the SR group (P < 0.01). LPL was associated with shorter postoperative hospital stay (mean 9.4 versus 14.9 days, P < 0.001) and lower 30-day mortality (3.5% versus 8.7%, P < 0.001). Diverticular disease-associated subsequent surgery was more common in the SR group than the LPL group except during the first year (P < 0.001). LPL had a lower mortality rate during the study period (stratified HR 0.70, 95% c.i. 0.53-0.92, P = 0.023).
    CONCLUSIONS: Laparoscopic lavage constitutes a safe alternative to sigmoid resection for selected patients judged clinically to require surgery.
    Diverticulitis is inflammation in pouches of the large bowel. Rarely, diverticulitis can lead to a bowel perforation causing peritonitis. Traditionally, it was treated by resection of the inflamed bowel with a stoma. A milder treatment has been proposed in which the abdomen is rinsed with saline laparoscopically and drained (laparoscopic lavage). This study aimed to examine the outcomes of laparoscopic lavage in Sweden. Our findings support the use of this method in younger and healthier patients with a history of no or only minor previous abdominal surgery.
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  • 文章类型: Journal Article
    背景:这项多中心病例对照研究旨在确定CT扫描HincheyIb-IIb和WSESIb-IIa憩室脓肿患者非手术治疗失败的危险因素。
    方法:本研究包括一组首次出现CT诊断憩室脓肿的成年患者,所有患者均接受了初始非手术治疗,包括单独使用抗生素或联合经皮引流.根据非手术治疗的结果对队列进行分层,特别确定需要紧急手术干预的患者为治疗失败的患者。采用多变量logistic回归分析确定非手术治疗失败的独立危险因素。
    结果:116例(27.04%)患者保守治疗失败。CT扫描Hinchey分类IIb(aOR2.54,95CI1.61;4.01,P<0.01),吸烟(aOR2.01,95CI1.24;3.25,P<0.01),脓肿内存在气泡(aOR1.59,95CI1.00;2.52,P=0.04)是失败的独立预测因子.在脓肿>5cm的患者亚组中,经皮穿刺引流与非手术治疗失败或成功的风险无关(aOR2.78,95CI-0.66;3.70,P=0.23).
    结论:对于憩室脓肿,非手术治疗通常是有效的。吸烟作为治疗失败的独立危险因素的作用强调了在憩室疾病管理中需要有针对性的行为干预措施。IIbHinchey憩室炎患者,尤其是年轻的吸烟者,由于治疗失败和脓毒症进展的风险增加,需要警惕监测。对图像引导经皮引流的疗效的进一步研究应包括随机,多中心研究侧重于同质患者群体。
    BACKGROUND: This multicentre case-control study aimed to identify risk factors associated with non-operative treatment failure for patients with CT scan Hinchey Ib-IIb and WSES Ib-IIa diverticular abscesses.
    METHODS: This study included a cohort of adult patients experiencing their first episode of CT-diagnosed diverticular abscess, all of whom underwent initial non-operative treatment comprising either antibiotics alone or in combination with percutaneous drainage. The cohort was stratified based on the outcome of non-operative treatment, specifically identifying those who required emergency surgical intervention as cases of treatment failure. Multivariable logistic regression analysis to identify independent risk factors associated with the failure of non-operative treatment was employed.
    RESULTS: Failure of conservative treatment occurred for 116 patients (27.04%). CT scan Hinchey classification IIb (aOR 2.54, 95%CI 1.61;4.01, P < 0.01), tobacco smoking (aOR 2.01, 95%CI 1.24;3.25, P < 0.01), and presence of air bubbles inside the abscess (aOR 1.59, 95%CI 1.00;2.52, P = 0.04) were independent predictors of failure. In the subgroup of patients with abscesses > 5 cm, percutaneous drainage was not associated with the risk of failure or success of the non-operative treatment (aOR 2.78, 95%CI - 0.66;3.70, P = 0.23).
    CONCLUSIONS: Non-operative treatment is generally effective for diverticular abscesses. Tobacco smoking\'s role as an independent risk factor for treatment failure underscores the need for targeted behavioural interventions in diverticular disease management. IIb Hinchey diverticulitis patients, particularly young smokers, require vigilant monitoring due to increased risks of treatment failure and septic progression. Further research into the efficacy of image-guided percutaneous drainage should involve randomized, multicentre studies focussing on homogeneous patient groups.
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  • 文章类型: Journal Article
    背景:如果认为急性憩室炎的治疗是安全的,目前的指南建议采用原发性吻合术和转移回肠造口术进行切除,而不是Hartmann手术。本研究的主要目的是比较这些策略的使用情况,并描述出院后1年内全国范围内的造口术闭合模式和再入院结局。
    方法:这是一个回顾性研究,以人口为基础,2011年1月至2019年12月美国医院向全国再入院数据库报告的队列研究。有35,774例患者被确定为接受非选择性原发性吻合术和分流回肠造口术或Hartmann手术治疗急性憩室炎。造口术闭合率,计划外再入院,并对并发症进行比较。使用Cox比例风险和逻辑回归模型来控制患者和医院级别的混杂因素以及疾病的严重程度。
    结果:在确定的35,774名患者中,93.5%接受了哈特曼手术。一半(47.2%)年龄在46-65岁之间,50.8%女性,41.2%的公共保险,91.7%接受了开放手术。原发性吻合与较高的1年造口闭合率相关(83.6%vs.53.4%,p<0.001)和更短的关闭时间[中位数72天(四分位数范围49-103)与115(86-160);p<0.001]。原发性吻合术与计划外再入院增加相关[危险比=2.83(95%置信区间2.83-3.37);p<0.001],但造口闭合后并发症较少[赔率比0.51(95%0.42-0.63);p<0.001]。初次吻合和Hartmann手术在初次入院期间的并发症没有差异[赔率=1.13(95%置信区间0.96-1.33);p=0.137]。
    结论:因急性憩室炎而接受原发性吻合术的患者更有可能进行造口逆转,造口逆转术后并发症较少。这些数据支持当前的国家指南,该指南建议在需要手术治疗的急性憩室炎的适当病例中进行初次吻合。
    BACKGROUND: Current guidelines recommend resection with primary anastomosis with diverting loop ileostomy over Hartmann\'s procedure if deemed safe for acute diverticulitis. The primary objective of the current study was to compare the utilization of these strategies and describe nationwide ostomy closure patterns and readmission outcomes within 1 year of discharge.
    METHODS: This was a retrospective, population-based, cohort study of United States Hospitals reporting to the Nationwide Readmissions Database from January 2011 to December 2019. There were 35,774 patients identified undergoing non-elective primary anastomosis with diverting loop ileostomy or Hartmann\'s procedure for acute diverticulitis. Rates of ostomy closure, unplanned readmissions, and complications were compared. Cox proportional hazards and logistic regression models were used to control for patient and hospital-level confounders as well as severity of disease.
    RESULTS: Of the 35,774 patients identified, 93.5% underwent Hartmann\'s procedure. Half (47.2%) were aged 46-65 years, 50.8% female, 41.2% publicly insured, and 91.7% underwent open surgery. Primary anastomosis was associated with higher rates of 1-year ostomy closure (83.6% vs. 53.4%, p < 0.001) and shorter time-to-closure [median 72 days (Interquartile range 49-103) vs. 115 (86-160); p < 0.001]. Primary anastomosis was associated with increased unplanned readmissions [Hazard Ratio = 2.83 (95% Confidence Interval 2.83-3.37); p < 0.001], but fewer complications upon stoma closure [Odds Ratio 0.51 (95% 0.42-0.63); p < 0.001]. There were no differences in complications between primary anastomosis and Hartmann\'s procedure during index admission [Odds Ratio = 1.13 (95% Confidence Interval 0.96-1.33); p = 0.137].
    CONCLUSIONS: Patients who undergo primary anastomosis for acute diverticulitis are more likely to undergo ostomy reversal and experience fewer postoperative complications upon stoma reversal. These data support the current national guidelines that recommend primary anastomosis in appropriate cases of acute diverticulitis requiring operative treatment.
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  • 文章类型: Meta-Analysis
    背景:评估门诊(OP)和住院(IP)治疗以及抗生素(ABX)和无抗生素(NABX)方法治疗无并发症(Hinchey1a级)急性憩室炎的比较结果。
    方法:使用电子数据库进行系统的在线搜索。包括OP与IP治疗以及ABX与NABX方法治疗Hinchey1a级急性憩室炎的比较研究。主要结果是憩室炎复发。急诊和选择性手术切除,复杂憩室炎的发展,死亡率,和住院时间是其他评估的次要结局参数.
    结果:文献检索确定了12项研究(n=3,875),比较了NABX(n=2,008)和ABX(n=1,867)。与ABX组相比,NABX组的疾病复发率较低,住院时间较短(P=0.01)和(P=0.004)。在急诊切除中没有观察到显著差异(P=0.33)。选择性切除(P=0.73),复杂憩室炎的发展(P=0.65),再入院率(P=0.65)和30天死亡率(P=0.91).12项研究(n=2,286)比较了OP(n=1,021)和IP(n=1,265)治疗无并发症的急性憩室炎。两组在以下结果方面具有可比性:治疗失败(P=0.10),急诊手术切除(P=0.40),择期切除(P=0.30),疾病复发(P=0.22),死亡率(P=0.61)。
    结论:在选定的无并发症急性憩室炎(Hinchey1a分类)的临床稳定患者中,仅观察治疗是可行且安全的。它可以提供更好的结果,包括缩短住院时间。此外,OP方法治疗Hinchey1a急性憩室炎患者与IP治疗相当.未来需要高质量的随机对照研究来了解在OP设置中使用NABX方法来管理无并发症的急性憩室炎患者的结果。
    BACKGROUND: To evaluate comparative outcomes of outpatient (OP) versus inpatient (IP) treatment and antibiotics (ABX) versus no antibiotics (NABX) approach in the treatment of uncomplicated (Hinchey grade 1a) acute diverticulitis.
    METHODS: A systematic online search was conducted using electronic databases. Comparative studies of OP versus IP treatment and ABX versus NABX approach in the treatment of Hinchey grade 1a acute diverticulitis were included. Primary outcome was recurrence of diverticulitis. Emergency and elective surgical resections, development of complicated diverticulitis, mortality rate, and length of hospital stay were the other evaluated secondary outcome parameters.
    RESULTS: The literature search identified twelve studies (n = 3,875) comparing NABX (n = 2,008) versus ABX (n = 1,867). The NABX group showed a lower disease recurrence rate and shorter length of hospital stay compared with the ABX group (P = 0.01) and (P = 0.004). No significant difference was observed in emergency resections (P = 0.33), elective resections (P = 0.73), development of complicated diverticulitis (P = 0.65), hospital re-admissions (P = 0.65) and 30-day mortality rate (P = 0.91). Twelve studies (n = 2,286) compared OP (n = 1,021) versus IP (n = 1,265) management of uncomplicated acute diverticulitis. The two groups were comparable for the following outcomes: treatment failure (P = 0.10), emergency surgical resection (P = 0.40), elective resection (P = 0.30), disease recurrence (P = 0.22), and mortality rate (P = 0.61).
    CONCLUSIONS: Observation-only treatment is feasible and safe in selected clinically stable patients with uncomplicated acute diverticulitis (Hinchey 1a classification). It may provide better outcomes including decreased length of hospital stay. Moreover, the OP approach in treating patients with Hinchey 1a acute diverticulitis is comparable to IP management. Future high-quality randomised controlled studies are needed to understand the outcomes of the NABX approach used in an OP setting in managing patients with uncomplicated acute diverticulitis.
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  • 文章类型: Journal Article
    目的:了解复发性憩室炎结肠切除术的患者决策过程。
    背景:对复发性憩室炎进行择期结肠切除术的决定是高度偏好敏感的。在这个决策过程中,对患者的观点知之甚少。
    方法:我们在美国三个中心对复发性憩室炎患者进行了一项定性研究。使用迭代归纳/演绎方法,我们开发了一个概念框架来捕获编码数据中确定的主要主题。
    结果:从2019年3月至2020年7月,在三个地点招募了39名患者,并参加了六个重点小组。在使用分层编码系统对转录本进行编码后,建立了一个概念框架。确定的主要主题包括:参与者对手术的信念,例如规范性信仰(例如,主观,对手术的价值),控制信念(例如,自我效能感,变化阶段)和预期结果(例如,期望,预期的遗憾);行为管理策略的作用(例如,纤维,消除不良习惯);情感体验(例如,抑郁症,尴尬);当前症状(例如,严重程度,时间安排);和生活质量(例如,认知负荷,社会心理因素)。确定了影响患者选择的三组调节因素:临床病史(例如,诊断的来源,多次手术),临床方案(例如,术前和术后教育)和提供者特定的因素(例如,专业,外科医生的选择)。
    结论:患者通过三个主要主题来看待接受结肠切除术的决定-他们对手术的信念,他们的社会心理背景和影响参与者选择手术的调节因素。这些知识对于咨询正在考虑结肠切除术的患者的临床医生以及研究优化复发性憩室炎护理过程的研究人员都是必不可少的。
    OBJECTIVE: Understand the patient\'s decision-making process regarding colectomy for recurrent diverticulitis.
    BACKGROUND: The decision to pursue elective colectomy for recurrent diverticulitis is highly preference-sensitive. Little is known about the patient\'s perspective in this decision-making process.
    METHODS: We performed a qualitative study utilizing focus groups of patients with recurrent diverticulitis at 3 centers across the United States. Using an iterative inductive/deductive approach, we developed a conceptual framework to capture the major themes identified in the coded data.
    RESULTS: From March 2019 to July 2020, 39 patients were enrolled across 3 sites and participated in 6 focus groups. After coding the transcripts using a hierarchical coding system, a conceptual framework was developed. Major themes identified included participants\' beliefs about surgery, such as normative beliefs (eg, subjective, value placed on surgery), control beliefs (eg, self-efficacy, stage of change), and anticipated outcomes (eg, expectations, anticipated regret); the role of behavioral management strategies (eg, fiber, eliminate bad habits); emotional experiences (eg, depression, embarrassment); current symptoms (eg, severity, timing); and quality of life (eg, cognitive load, psychosocial factors). Three sets of moderating factors influencing patient choice were identified: clinical history (eg, source of diagnosis, multiple surgeries), clinical protocols (eg, pre-op and post-op education), and provider-specific factors (eg, specialty, choice of surgeon).
    CONCLUSIONS: Patients view the decision to undergo colectomy through 3 major themes: their beliefs about surgery, their psychosocial context, and moderating factors that influence participant choice to undergo surgery. This knowledge is essential both for clinicians counseling patients who are considering colectomy and for researchers studying the process to optimize care for recurrent diverticulitis.
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  • 文章类型: Case Reports
    孤立性横结肠憩室的憩室炎并不常见,文献中只有少数案例记录。该病有多种临床表现,这使得临床和放射学诊断相当具有挑战性。在这里,我们介绍了一个40多岁的绝经前女性患者到急诊科就诊,抱怨右下腹腹痛,恶心,厌食症和发烧。在临床之后,生化和放射学测试,病人准备手术,推测诊断为急性阑尾炎.计划通过McBurney切口进行阑尾切除术。值得注意的是,没有发现阑尾发炎。然而,进一步探索,在横结肠发现了一个炎性肿块,随后切除并送去进行组织学检查。组织学结果证实存在单发横结肠憩室破裂,伴有邻近的肠系膜脓肿。患者术后恢复顺利。
    Diverticulitis in a solitary transverse colon diverticulum is uncommon, with only a handful of cases documented in the literature. There are various clinical manifestations of the disease, which make clinical and radiological diagnosis rather challenging. Herein, we present a case of a premenopausal female patient in her late 40s who presented to the emergency department, complaining of right lower quadrant abdominal pain, nausea, anorexia and fever. Following clinical, biochemical and radiological tests, the patient was prepared for surgical operation, with the presumed diagnosis of acute appendicitis. An appendicectomy was planned via a McBurney incision. Notably, no inflammation of the appendix was discovered. However, on further exploration, an inflammatory mass was identified in the transverse colon, which was subsequently excised and sent for histological examination. The histology results confirmed the presence of a ruptured solitary transverse colon diverticulum, accompanied by an adjacent mesenteric abscess. The patient\'s postoperative recovery was uneventful.
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