背景:腹膜透析(PD)是治疗晚期肾衰竭的有效方法,为患者提供很大程度的独立性。然而,由于腹膜的变性,PD的长期使用受到限制,导致透析充分性降低。使用现有方法评估正在接受PD的晚期肾衰竭患者的腹膜状况具有挑战性。因此,本研究旨在探讨PD患者腹腔液中8-羟基-2'-脱氧鸟苷(8OHDG)水平与各种因素的相关性,如腹膜平衡试验(PET),透析充分性(Kt/V),潜在的疾病,血清铁蛋白,和白蛋白水平。8OHDG是氧化应激惹起DNA毁伤的敏感标记物。
方法:本横断面研究共纳入56例患者。从患者身上收集了五毫升的PD液,采用ELISA法测定8-OHdG水平。然后,将它们与PET进行比较,Kt/V,白蛋白,和病人档案中的铁蛋白标记,并对结果进行统计学检验分析。
结果:该研究检查了8OHDG与其他标志物之间的相关性。发现该指数与PET和潜在的HTN有显著关联(P<0.05)。而与其他标记没有发现显著关联。
结论:本研究的结果表明,8OHDG的水平,作为氧化应激标志物之一,可用于评估PD患者的腹膜功能。DOI:10.52547/ijkd.7654。
Peritoneal dialysis (PD) is an effective treatment modality for advanced kidney failure, offering patients a significant degree of independence. However, the long-term use of PD is limited due to the degeneration of the peritoneal membrane, resulting in reduced dialysis adequacy. Evaluating the peritoneal membrane condition in patients with advanced kidney failure who are undergoing PD is challenging with existing methods. Therefore, this study aimed to investigate the correlation between 8-hydroxy-2\'-
deoxyguanosine (8OHDG) levels in the peritoneal solution of patients undergoing PD and various factors, such as peritoneal equilibration test (PET), dialysis adequacy (Kt/V), underlying diseases, serum ferritin, and albumin levels. 8OHDG is a sensitive marker of oxidative stress caused by DNA damage.
A total of 56 patients were included in this cross-sectional study. Five milliliters of PD fluid were collected from the patients, and 8-OHdG levels were measured using ELISA method. Then, they were compared with PET, Kt/V, albumin, and ferritin markers in the patients\' files, and the results were analyzed by statistical tests.
The study examined the correlation between 8OHDG and other markers. It was found that this index had significant associations with PET and underlying HTN (P < .05), whereas no significant associations were identified with the other markers.
The results of the present study demonstrate that the level of 8OHDG, as one of the oxidative stress markers, could be used to evaluate the function of the peritoneum in patients undergoing PD. DOI: 10.52547/ijkd.7654.