目的:评估高压氧治疗(HBOT)对克罗利纳科毒素引起的犬伤口肿胀,严重程度和疼痛的影响,并描述HBOT的安全性和并发症。
方法:前瞻性,随机化,控制,盲法研究(2017-2021年)。
方法:大学教学医院,私人兽医实践。
方法:在2017年至2021年之间,招募了36只在确认或疑似自然发生的Crotalinae蛇咬伤后24小时内出现的客户拥有的狗。
方法:除了标准的护理治疗,犬在入院24小时内接受了2次HBOT(n=19)或对照(n=16)干预.接受HBOT的狗在15分钟内加压(1psi/min),在2个绝对大气压(ATA)的目标压力下保持30分钟,并在15分钟内减压。对照狗接受1ATA持续1小时。局部伤口肿胀,伤口严重程度评分,入院时评估疼痛评分,在每次干预之前和之后,出院时.
结果:伤口肿胀没有显着差异(P=0.414),严重程度评分(P=1.000),HBOT组和对照组的疼痛评分(P=0.689)。无论采用何种研究干预,疼痛随时间显著降低(P<0.001)。没有与任何一项研究干预相关的主要不良反应。
结论:HBOT并没有显著改变本研究人群中的短时期克龙毒素恢复。然而,这项研究可能不足以检测到显著的治疗效果。
OBJECTIVE: To assess the effect of hyperbaric oxygen therapy (HBOT) on
Crotalinae envenomation-induced wound swelling and severity and pain in dogs, and to describe the safety and complications of HBOT.
METHODS: Prospective, randomized, controlled, blinded study (2017-2021).
METHODS: University teaching hospital, private veterinary practice.
METHODS: Thirty-six client-owned dogs presenting within 24 hours of a confirmed or suspected naturally occurring
Crotalinae snake bite injury were enrolled between 2017 and 2021.
METHODS: In addition to the standard of care treatment, dogs received 2 interventions with either HBOT (n = 19) or control (n = 16) within 24 hours of hospital admission. Dogs receiving HBOT were pressurized over 15 minutes (1 psi/min), maintained at a target pressure of 2 atmosphere absolute (ATA) for 30 minutes, and decompressed over 15 minutes. Control dogs received 1 ATA for 1 hour. Local wound swelling, wound severity score, and pain score were assessed at admission, before and after each intervention, and at hospital discharge.
RESULTS: There was no significant difference in wound swelling (P = 0.414), severity score (P = 1.000), or pain score (P = 0.689) between HBOT and control groups. Pain decreased significantly over time regardless of the study intervention (P < 0.001). There were no major adverse effects associated with either study intervention.
CONCLUSIONS: HBOT did not significantly alter the short-term recovery from
Crotalinae envenomation in this study population. However, the study might be underpowered to detect a significant treatment effect.