目的:对人类初级运动皮质重复经颅磁刺激(TMS)的重复间隔会话可导致运动皮质兴奋性的剂量依赖性增加。然而,这尚未在确定的皮质回路中得到证实.我们旨在研究重复间隔的皮层配对联想刺激(cPAS)对运动皮层兴奋性的影响。
方法:cPAS通过两个线圈输送到初级运动皮层(M1)和后顶叶皮层(PPC)。在多剂量条件下,三次cPAS间隔50分钟。单剂量条件有一次cPAS,随后是控制cPAS协议的两个会话。在每次cPAS疗程之前和之后40分钟内评估运动诱发电位,以衡量皮质兴奋性。
结果:与单剂量cPAS相比,多剂量cPAS后,运动皮质兴奋性显着增加。cPAS会议次数的增加导致了累积,对运动皮质兴奋性的剂量依赖性作用,每个连续的cPAS会话导致增强显着增加。
结论:重复间隔的cPAS课程总结以增加单个cPAS诱导的运动皮质兴奋性。
结论:重复间隔的cPAS可能会恢复因中风等疾病而丧失的能力。
OBJECTIVE: Repeated spaced sessions of repetitive transcranial magnetic stimulation (TMS) to the human primary motor cortex can lead to dose-dependent increases in motor cortical excitability. However, this has yet to be demonstrated in a defined cortical circuit. We aimed to examine the effects of repeated spaced cortical paired associative stimulation (cPAS) on excitability in the motor cortex.
METHODS: cPAS was delivered to the primary motor cortex (M1) and posterior parietal cortex (PPC) with two coils. In the multi-dose condition, three sessions of cPAS were delivered 50-min apart. The single-dose condition had one session of cPAS, followed by two sessions of a control cPAS protocol. Motor-evoked potentials were evaluated before and up to 40 min after each cPAS session as a measure of cortical excitability.
RESULTS: Compared to a single dose of cPAS, motor cortical excitability significantly increased after multi-dose cPAS. Increasing the number of cPAS sessions resulted in a cumulative, dose-dependent effect on excitability in the motor cortex, with each successive cPAS session leading to notable increases in potentiation.
CONCLUSIONS: Repeated spaced cPAS sessions summate to increase motor cortical excitability induced by single cPAS.
CONCLUSIONS: Repeated spaced cPAS could potentially restore abilities lost due to disorders like stroke.