背景:据报道,肌张力障碍中皮质-基底神经节-丘脑-皮质(CBGTC)环的4-12Hz振荡活动增加。相干性分析是测量两个信号之间的线性耦合,揭示了在电机单元中常见的振荡活动驱动。通过进行一致性分析,CBGTC环的活动可以用局部场电位(LFP)等模态来测量,肌电图(EMG),和脑电图(EEG)。这项研究的目的是对一致性分析在肌张力障碍的临床评估和治疗中的应用进行系统评价。
方法:6月28日在Embase和PubMed进行了系统评价,2023年。纳入了所有纳入相干性分析和成人肌张力障碍队列的研究。三位作者评估了文章的资格。使用QUADAS-2检查表评估质量。
结果:共纳入41篇文章,395名成年肌张力障碍患者的数据。在选定的记录中,研究了六种不同类型的相干性:皮质皮质,皮质,皮质醇,苍白球,苍白球,和肌肉间的连贯性。在所有肌张力障碍亚型中发现各种类型的4-12相干性增加。
结论:皮层之间的4-12Hz相干性增加,基底神经节,并影响所有肌张力障碍亚型的肌肉。然而,4和12Hz相干性与肌张力障碍临床状态之间的关系尚未建立。DBS处理导致4-12Hz相干性的降低。结合本综述的结果,4-12Hz频带可以用作生物标志物开发的有希望的现象。
BACKGROUND: Increased 4-12 Hz oscillatory activity in the cortico-basal ganglia-thalamo-cortical (CBGTC) loop is reported in dystonia.
Coherence analysis is a measure of linear coupling between two signals, revealing oscillatory activity drives that are common across motor units. By performing coherence analysis, activity of the CBGTC-loop can be measured with modalities like local field potentials (LFPs), electromyography (EMG), and electro-encephalography (EEG). The aim of this study is to perform a systematic review on the use of coherence analysis for clinical assessment and treatment of dystonia.
METHODS: A systematic review was performed on a search in Embase and PubMed on June 28th, 2023. All studies incorporating
coherence analysis and an adult dystonia cohort were included. Three authors evaluated the eligibility of the articles. Quality was assessed using the QUADAS-2 checklist.
RESULTS: A total of 41 articles were included, with data of 395 adult dystonia patients. In the selected records, six different types of coherence were investigated: corticocortical, corticopallidal, corticomuscular, pallidopallidal, pallidomuscular, and intermuscular
coherence. Various types of 4-12
coherence were found to be increased in all dystonia subtypes.
CONCLUSIONS: There is increased 4-12 Hz coherence found between the cortex, basal ganglia, and affected muscles in all dystonia subtypes. However, the relationship between 4-12 Hz coherence and the dystonic clinical state has not been established. DBS treatment leads to a reduction of 4-12 Hz
coherence. In combination with the results of this review, the 4-12 Hz frequency band can be used as a promising phenomenon for the development of a biomarker.