PDF(Pubmed)
Abstract：
Understanding the response of the injured brain to different transcranial direct current stimulation (tDCS) montages may help explain the variable tDCS treatment results on poststroke motor gains. Cortical connectivity has been found to reflect poststroke motor gains and cortical plasticity, but the changes in connectivity following tDCS remain unknown. We aimed to investigate the relationship between tDCS-induced changes in cortical connectivity and poststroke motor gains. In this study, participants were assigned to receive four tDCS montages (anodal, cathodal, bilateral, and sham) over the primary motor cortex (M1) according to a single-blind, randomized, crossover design. Electroencephalography (EEG) and Jebsen-Taylor hand function test (JTT) were performed before and after the intervention. Motor cortical connectivity was measured using beta-band coherence with the ipsilesional and contralesional M1 as seed regions. Motor gain was evaluated based on the JTT completion time. We examined the relationship between baseline connectivity and clinical characteristics and that between changes in connectivity and motor gains after different tDCS montages. Baseline functional connectivity, motor impairment, and poststroke duration were correlated. High ipsilesional M1-frontal-temporal connectivity was correlated with a good baseline motor status, and increased connectivity was accompanied by good functional improvement following anodal tDCS treatment. Low contralesional M1-frontal-central connectivity was correlated with a good baseline motor status, and decreased connectivity was accompanied by good functional improvement following cathodal tDCS treatment. In conclusion, EEG-based motor cortical connectivity was correlated with stroke characteristics, including motor impairment and poststroke duration, and motor gains induced by anodal and cathodal tDCS.
摘要：
了解受伤的大脑对不同的经颅直流电刺激（tDCS）蒙太奇的反应可能有助于解释中风后运动增益的可变tDCS治疗结果。已发现皮质连通性反映了中风后的运动增益和皮质可塑性，但是tDCS之后的连通性变化仍然未知。我们旨在研究tDCS诱导的皮质连通性变化与卒中后运动增益之间的关系。在这项研究中,参与者被分配接受四个tDCS蒙太奇(阳极，Cathodal,双边,和假)在初级运动皮层(M1)上，根据单盲，随机化，交叉设计。干预前后分别进行脑电图（EEG）和Jebsen-Taylor手功能测试（JTT）。使用β带相干性以同侧和对侧M1作为种子区域来测量运动皮层连通性。基于JTT完成时间评估运动增益。我们检查了基线连通性与临床特征之间的关系，以及不同tDCS蒙太奇后连通性变化与运动增益之间的关系。基线功能连接，运动障碍,与卒中后持续时间相关。高同侧M1-额-颞连通性与良好的基线运动状态相关，连接增加伴随着阳极tDCS治疗后良好的功能改善。对比M1-额叶-中央连通性低与良好的基线运动状态相关，在阴极tDCS治疗后，连通性下降伴随着良好的功能改善。总之,基于EEG的运动皮层连通性与卒中特征相关，包括运动障碍和中风后持续时间，阳极和阴极tDCS引起的运动增益。
