目的:本研究旨在通过耳蜗电描记术(ECochG)的发现来探索慢性耳鸣患者的电生理特征,并确定这些发现是否与特定的听力学模式相关,这些模式可以区分耳鸣患者和没有耳鸣的患者。
方法:对2020年3月至2023年12月在三级大学医院就诊耳鸣诊所的患者的病历进行了回顾性分析。纳入标准为持续三个月以上的非搏动性主观耳鸣,和ECochG在初始评估时进行。对听力学评估和ECochG结果进行了分析,SP/AP比率是一个焦点。
结果:在256名患者中,在37.5%的患者中观察到SP/AP比值升高.根据耳鸣侧向性,ECochG结果没有显着差异。SP/AP比值升高的患者报告了更多的睡眠障碍,更高的抑郁分数,注意问题,和听觉丰满。这些患者还表现出较低的响度不适水平和低频听力损失。SP/AP比值升高与DPOAE反应显著相关。
结论:研究结果强调了ECochG中的SP/AP比率是评估耳鸣的临床和心理方面的有价值的生物标志物,表明其在定制治疗策略方面的潜在效用。SP/AP比率升高与睡眠障碍有关,抑郁症,注意问题,听觉丰满,高音,和低频听力损失,这表明耳蜗病理学和耳鸣感知之间存在复杂的相互作用。这项研究强调了在耳鸣的临床评估中需要对ECochG结果进行细致的理解,可能指导更个性化的管理方法。
OBJECTIVE: This study aimed to explore the electrophysiological characteristics of patients with chronic tinnitus through electrocochleography (ECochG) findings and determine if these findings correlate with specific audiological patterns that could differentiate tinnitus patients from those without this condition.
METHODS: A retrospective analysis of medical records from patients who visited a tinnitus clinic at a tertiary university hospital between March 2020 and December 2023 was conducted. Inclusion criteria were non-pulsatile subjective tinnitus lasting over three months, and ECochG performed at initial evaluation. Audiological assessments and ECochG results were analyzed, with the SP/AP ratio being a focal point.
RESULTS: Among 256 patients, an elevated SP/AP ratio was observed in 37.5 % of patients. No significant difference in ECochG outcomes was noted based on tinnitus laterality. Patients with an elevated SP/AP ratio reported more sleep disturbances, higher depression scores, attention problems, and aural fullness. These patients also exhibited lower loudness discomfort levels and low-frequency hearing losses. Significant correlations were found between elevated SP/AP ratios and DPOAE responses.
CONCLUSIONS: The findings highlight the SP/AP ratio in ECochG as a valuable biomarker for assessing clinical and psychological aspects of tinnitus, indicating its potential utility in tailoring treatment strategies. Elevated SP/AP ratios were associated with sleep disturbances, depression, attention problems, aural fullness, hyperacusis, and low-frequency hearing loss, suggesting a complex interplay between cochlear pathology and tinnitus perception. This study underscores the need for a nuanced understanding of ECochG results in the clinical evaluation of tinnitus, potentially guiding more personalized management approaches.