背景:高胰岛素血症是与耳蜗前庭疾病相关的最常见的代谢变化。
目的:我们旨在研究高胰岛素血症个体的听觉功能。
方法:本病例对照研究共纳入164例患者。而76例胰岛素抵抗患者(胰岛素抵抗稳态模型评估[HOMA-IR]≥2.5)构成病例组,88例HOMA-IR值<2.5的患者构成本研究的对照组。
方法:75g口服葡萄糖耐量试验,血液生化测试,荷尔蒙分析,听力学评估,耳蜗电图(EcochG),并进行了瞬态诱发耳声发射(TEOAE)测试。
方法:使用单向方差分析和Kruskal-Wallis方差分析比较正常糖耐量(NGT)的代谢和耳朵参数,空腹血糖受损(IFG),糖耐量受损(IGT)组。卡方检验用于比较名义变量。采用Spearman和Pearson相关系数对连续变量进行相关性分析。
结果:病例组在0.5、1、2和4kHz的纯音测听优于对照组。HbA1c与右耳0.5、1、4和8kHz阈值与左耳2、4、6和8kHz阈值之间存在正相关。HbA1c与言语歧视得分呈负相关。发现NGT患者的右耳1.00和2.83kHzTEOAE测量值高于IGT患者,发现1.42kHzTEOAE测量值和可重复性高于IFG患者。IGT患者的左耳1.00和1.42kHzTEOAE测量值低于IFG和NGT患者。
结论:我们表明,高胰岛素血症患者的听力恶化,糖尿病前期的状况与听力功能损害有关。
BACKGROUND: Hyperinsulinemia is the most common metabolic change associated with cochleovestibular diseases.
OBJECTIVE: We aimed to investigate the auditory functions in hyperinsulinemic individuals.
METHODS: A total of 164 patients were included in this case-control study. While 76 patients with insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] of ≥2.5) constituted the case group, 88 patients with HOMA-IR values of <2.5 constituted the control group of the study.
METHODS: The 75 g oral glucose tolerance test, blood biochemistry tests, hormonal analysis, audiological assessment, electrocochleography (EcochG), and transient evoked otoacoustic emissions (TEOAE) testing were performed.
METHODS: One-way analysis of variance and Kruskal-Wallis analysis of variance were used for the comparison of the metabolic and ear parameters in the normal glucose tolerance (NGT), impaired fasting glucose (IFG), and impaired glucose tolerance (IGT) groups. The chi-square test was used to compare nominal variables. Spearman and Pearson correlation coefficients were used for the correlation analyses of continuous variables.
RESULTS: The pure tone audiometry at 0.5, 1, 2, and 4 kHz was better in the case group than in the control group. A positive correlation was found between HbA1c and right ear 0.5, 1, 4, and 8 kHz threshold values and left ear 2, 4, 6, and 8 kHz threshold values. A negative correlation was found between HbA1c and speech discrimination scores. The right ear 1.00 and 2.83 kHz TEOAE measurements in the individuals with NGT were found higher than those in patients with IGT, and the 1.42 kHz TEOAE measurements and reproducibility were found higher than those in patients with IFG. The left ear 1.00 and 1.42 kHz TEOAE measurements of the IGT patients were found lower than those of IFG and NGT patients.
CONCLUSIONS: We showed that hearing was worsening in hyperinsulinemic patients and prediabetic conditions were related to hearing function impairment.