目的:确定不同运动方式与不同训练周期的不同组合对乳腺癌患者生活质量和疼痛症状的改善作用。
方法:数据库PubMed,WebofScience,Embase,和Scopus通过计算机网络进行搜索,搜索截止日期为2023年8月23日。两名研究人员独立筛选了文献,提取数据并对纳入文献进行方法学质量评估,然后使用stata17.0进行相应的统计分析和绘图。
结果:纳入了36项随机对照试验(RCT)研究,涉及3003名参与者和7种运动方式。与常规护理相比,大多数锻炼方式改善了患者的生活质量,长期有氧联合抗阻运动[SMD=0.83,95%CI=0.34,1.33,p=0.001]和YOGA[SMD=0.61,95%CI=0.06,1.16,p=0.029]治疗效果显著。对于疼痛和疲劳相关的结果指标,与对照组相比,分析中包含的所有运动方式的治疗效果均不显著,但往往对患者有益。
结论:长期有氧运动结合抗阻运动对改善乳腺癌患者的生活质量和疲劳状态最有效。有氧运动对改善乳腺癌患者的疼痛症状更有效。
OBJECTIVE: To determine the effect of different combinations of different exercise modalities with different training cycles on the improvement of quality of life and pain symptoms in breast cancer patients.
METHODS: The databases PubMed, Web of Science, Embase, and Scopus were searched through a computer network with a search deadline of 23 August 2023. Two researchers independently screened the literature, extracted data and performed methodological quality assessment of the included literature, and then performed the corresponding statistical analyses and graphing using stata17.0.
RESULTS: Thirty-six randomized control trial (RCT) studies involving 3003 participants and seven exercise modalities were included. Most of the exercise modalities improved patients\' quality of life compared to usual care, with long-term aerobic combined with resistance exercise [SMD = 0.83,95% CI = 0.34,1.33,p = 0.001] and YOGA [SMD = 0.61,95% CI = 0.06,1.16,p = 0.029] treatments having a significant effect. For pain and fatigue-related outcome indicators, the treatment effect was not significant for all exercise modalities included in the analysis compared to the control group, but tended to be beneficial for patients.
CONCLUSIONS: Long-term aerobic combined with resistance exercise was the most effective in improving quality of life and fatigue status in breast cancer patients, and aerobic exercise was more effective in improving pain symptoms in breast cancer patients.