PDF(Pubmed)
Abstract：
Pain is one of the most common symptoms in patients with cancer. Pain not only negatively affects the quality of life of patients with cancer, but it has also been associated with reduced survival. Pain management is therefore a critical component of cancer care. Prescription opioids remain the first-line approach for the management of moderate-to-severe pain associated with cancer. However, there has been increasing interest in understanding whether these analgesics could impact cancer progression. Furthermore, epidemiological data link a possible association between prescription opioid usage and cancer development. Until more robust evidence is available, patients with cancer with moderate-to-severe pain may receive opioids to decrease suffering. However, future studies should be conducted to evaluate the role of opioids and opioid receptors in specific cancers.
摘要：
疼痛是癌症患者最常见的症状之一。疼痛不仅会对癌症患者的生活质量产生负面影响，但它也与生存率降低有关。因此，疼痛管理是癌症护理的重要组成部分。处方阿片类药物仍然是治疗与癌症相关的中度至重度疼痛的一线方法。然而,人们对了解这些镇痛药是否会影响癌症进展越来越感兴趣.此外，流行病学数据将处方阿片类药物使用与癌症发展之间可能存在关联。在有更有力的证据之前，患有中度至重度疼痛的癌症患者可以接受阿片类药物以减轻痛苦.然而,未来的研究应该评估阿片类药物和阿片受体在特定癌症中的作用.
