Abstract：
Introduction: Methadone is used to treat intractable cancer pain when other opioid analgesics are ineffective. Methadone tablets may be difficult to administer in cases of gastrointestinal passage obstruction. However, changing the route of methadone tablet administration is possible. Case Description: The patient, diagnosed with esophagogastric junction cancer with multiple metastases, continued to receive methadone tablets even after not being longer able to take oral medication. Method: Methadone tablets were administered using a simple suspension method via gastrostomy. We measured the respiratory rate during sleep daily. We also measured weekly QTc values using a 12-lead electrocardiogram and methadone blood concentration periodically. No side effects were observed. Conclusion: Using a simple suspension method to administer methadone is a safe pain management method when accompanied by careful monitoring. To date, no study has examined the tube administration safety of methadone tablets. Thus, this case report is of important clinical significance.
摘要：
简介：当其他阿片类镇痛药无效时，美沙酮用于治疗顽固性癌症疼痛。美沙酮片剂在胃肠道阻塞的情况下可能难以给药。然而,改变美沙酮片剂的给药途径是可能的。病例描述：患者，诊断为食管胃结合部癌伴多发转移，继续接受美沙酮片剂，即使不再能够服用口服药物。方法：美沙酮片通过胃造口术使用简单的悬浮方法给药。我们每天测量睡眠期间的呼吸频率。我们还定期使用12导联心电图和美沙酮血药浓度测量每周QTc值。没有观察到副作用。结论：使用简单的悬浮方法施用美沙酮是一种安全的疼痛管理方法，同时伴有仔细的监测。迄今为止,没有研究检查美沙酮片的管给药安全性。因此，该病例报告具有重要的临床意义。
