■确定首次诊断为1型糖尿病(T1DM)的个体的骨髓脂肪含量是否有改变,并探讨骨髓脂肪分数与基于MRI的小梁骨微结构发现之间的关联。
■进行了病例对照研究,涉及首次诊断为T1DM的成年人(n=35)和年龄和性别匹配的健康成年人(n=46)。对胫骨近端进行了双能X线吸收法和3Tesla-MRI,以评估小梁微结构和骨髓脂肪分数。使用多元线性回归分析来测试骨髓脂肪分数与小梁微结构和骨密度的关联,同时调整潜在的混杂因素。
■在首次诊断为T1DM的个体中,骨髓脂肪分数显著高于健康对照组(p<0.001).T1DM患者还表现出较高的小梁分离[中位数(IQR):2.19(1.70,2.68)vs1.81(1.62,2.10),p<0.001],小梁体积较低[0.45(0.30,0.56)对0.53(0.38,0.60),p=0.013],和较低的骨小梁数量[0.37(0.26,0.44)对0.41(0.32,0.47),与对照相比,p=0.020]。然而,两组的骨密度相似(p=0.815).在患有T1DM的个体中,骨髓脂肪分数与骨小梁体积(r=-0.69,p<0.001)和骨小梁数量(r=-0.55,p<0.001)呈负相关,与小梁分离呈正相关(r=0.75,p<0.001)。骨髓脂肪分数与总小梁体积独立相关(标准化β=-0.21),骨小梁数(β=-0.12),和骨小梁分离(β=0.57)的近端胫骨调整后的各种因素,包括年龄,性别,身体质量指数,身体活动,吸烟状况,酒精消费,血糖,血浆糖化血红蛋白,血脂谱,和骨转换生物标志物。
■首次诊断为T1DM的个体经历骨髓肥胖扩张,骨髓脂肪含量升高与基于MRI的小梁微结构有关。
UNASSIGNED: To determine whether there are alterations in marrow fat content in individuals first-time diagnosed with type 1 diabetes mellitus (T1DM) and to explore the associations between marrow fat fraction and MRI-based findings in trabecular bone microarchitecture.
UNASSIGNED: A case-control study was conducted, involving adults with first-time diagnosed T1DM (n=35) and age- and sex-matched healthy adults (n=46). Dual-energy X-ray absorptiometry and 3 Tesla-MRI of the proximal tibia were performed to assess trabecular microarchitecture and vertebral marrow fat fraction. Multiple linear regression analysis was used to test the associations of marrow fat fraction with trabecular microarchitecture and bone density while adjusting for potential confounding factors.
UNASSIGNED: In individuals first-time diagnosed with T1DM, the marrow fat fraction was significantly higher (p < 0.001) compared to healthy controls. T1DM patients also exhibited higher trabecular separation [median (IQR): 2.19 (1.70, 2.68) vs 1.81 (1.62, 2.10), p < 0.001], lower trabecular volume [0.45 (0.30, 0.56) vs 0.53 (0.38, 0.60), p = 0.013], and lower trabecular number [0.37 (0.26, 0.44) vs 0.41 (0.32, 0.47), p = 0.020] compared to controls. However, bone density was similar between the two groups (p = 0.815). In individuals with T1DM, there was an inverse association between marrow fat fraction and trabecular volume (r = -0.69, p < 0.001) as well as trabecular number (r = -0.55, p < 0.001), and a positive association with trabecular separation (r = 0.75, p < 0.001). Marrow fat fraction was independently associated with total trabecular volume (standardized β = -0.21), trabecular number (β = -0.12), and trabecular separation (β = 0.57) of the proximal tibia after adjusting for various factors including age, gender, body mass index, physical activity, smoking status, alcohol consumption, blood glucose, plasma glycated hemoglobin, lipid profile, and bone turnover biomarkers.
UNASSIGNED: Individuals first-time diagnosed with T1DM experience expansion of marrow adiposity, and elevated marrow fat content is associated with MRI-based trabecular microstructure.