Abstract：
Scaffolds are an essential component of bone tissue engineering to provide support and create a physiological environment for cells. Biomimetic scaffolds are a promising approach to fulfill the requirements. Bone allografts are widely used scaffolds due to their mechanical and structural characteristics. The scaffold geometry is well known to be an important determinant of induced mechanical stimulation felt by the cells. However, the impact of allograft geometry on permeability and wall shear stress distribution is not well understood. This information is essential for designing biomimetic scaffolds that provide a suitable environment for cells to proliferate and differentiate. The present study investigates the effect of geometry on the permeability and wall shear stress of bone allografts at both macroscopic and microscopic scales. Our results concluded that the wall shear stress was strongly correlated with the porosity of the allograft. The level of wall shear stress at a local scale was also determined by the surface curvature characteristics. The results of this study can serve as a guideline for future biomimetic scaffold designs that provide a mechanical environment favorable for osteogenesis and bone repair.
摘要：
支架是骨组织工程的重要组成部分，为细胞提供支持和创造生理环境。仿生支架是满足要求的一种有前途的方法。同种异体骨由于其机械和结构特征而被广泛使用。众所周知，支架的几何形状是细胞感受到的诱导机械刺激的重要决定因素。然而,同种异体移植物几何形状对渗透率和壁面剪应力分布的影响尚不清楚。这些信息对于设计为细胞增殖和分化提供合适环境的仿生支架至关重要。本研究在宏观和微观尺度上研究了几何形状对同种异体骨的渗透性和壁切应力的影响。我们的结果得出结论，壁切应力与同种异体移植物的孔隙率密切相关。局部尺度下的壁面剪应力水平也由表面曲率特性决定。这项研究的结果可以作为未来仿生支架设计的指南，这些仿生支架设计提供了有利于成骨和骨修复的机械环境。
