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Abstract：
The TBS is a new method for clinicians to assess the bone quality. It is directly related to the mechanical strength of bone and helps predict fracture risk. The present analysis aimed to investigate the associations between serum PTH levels and TBS by analyzing data from the National Health and Nutrition Examination Survey (NHANES). A total of 3516 participants from the NHANES 2005-2006 were included in this cross-sectional study. The independent variable was serum PTH, and the outcome variable was TBS. The associations of serum PTH levels with TBS were examined using multivariable linear regression models. After adjusting for covariates, there was a negative association between serum PTH level and TBS (β = - 0.0034; 95% confidence interval, - 0.0050 to - 0.0017). However, in the subgroup analysis stratified by gender, race, and age, this association became negative only in Non-Hispanic White (β = - 0.0047, 95% CI: - 0.0071 to - 0.0048) and young people (age < 60) (β = - 0.0036, 95% CI: - 0.0057, - 0.0016), regardless of gender. In addition, the association of serum PTH with TBS was an U-shaped curve, with a point of inflection at 6.71 pmol/L. This study showed that serum PTH level was negatively associated with TBS. Maintaining PTH levels in a lower reasonable clinical range may be beneficial to bone health, especially for young non-Hispanic white.
摘要：
TBS是临床医生评估骨质量的新方法。它与骨的机械强度直接相关，有助于预测骨折风险。本分析旨在通过分析国家健康与营养调查（NHANES）的数据来研究血清PTH水平与TBS之间的关联。来自NHANES2005-2006的总共3516名参与者被纳入这项横断面研究。自变量为血清PTH,结果变量为TBS。使用多变量线性回归模型检查血清PTH水平与TBS的相关性。在调整协变量后，血清PTH水平与TBS呈负相关(β=-0.0034；95%置信区间，-0.0050至-0.0017）。然而,在按性别分层的亚组分析中，种族,和年龄,仅在非西班牙裔白人（β=-0.0047，95％CI：-0.0071至-0.0048）和年轻人（年龄<60）（β=-0.0036，95％CI：-0.0057，-0.0016）中，不分性别。此外,血清PTH与TBS呈U型曲线,拐点为6.71pmol/L。这项研究表明，血清PTH水平与TBS呈负相关。将PTH水平维持在较低的合理临床范围可能有益于骨骼健康。尤其是年轻的非西班牙裔白人。
