背景:心脏代谢疾病涵盖一系列与代谢功能障碍和/或心血管疾病相关的相关疾病,包括全身性动脉高血压,糖尿病,血脂异常,和肥胖。可可是膳食多酚的丰富来源,并且与心血管健康益处有关。然而,可可消费的有益效果和减少心脏代谢危险因素的适当数量尚未确定。因此,我们将进行系统评价和荟萃分析,以检查可可消费对心脏代谢风险标志物(总胆固醇,HDL,LDL,甘油三酯,血糖,糖化血红蛋白,腰围,腹围,身体质量指数,收缩压和舒张压)在有或没有确定的心血管危险因素的成年人中。
方法:我们的综述将包括所有以英文发表的随机对照试验,葡萄牙语和西班牙语,没有发布日期限制,评估可可消费对从数据库MEDLINE(PubMed)中选择的心脏代谢风险标志物的影响,LILACS,科克伦,EMBASE,WebofScienceandSciELO,灰色文学符合条件的研究必须涉及成年人(年龄≥18岁),和可可或黑巧克力的消费(≥70%可可),包括一个对照组并评估血压,人体测量,和脂质或血糖分布。我们将使用偏倚风险2(RoB2)工具来评估偏倚风险,并使用GRADE系统来评估证据的强度。统计分析将使用RStudioforWindows和R软件包meta进行。
结论:本荟萃分析将总结有关可可消费对成年人心脏代谢健康影响的现有证据。更好地了解可可消费对人体测量的影响,血压,和脂质和血糖谱可以为卫生专业人员提供有价值的见解,以改善有关适当数量的饮食建议。
背景:系统审查注册:PROSPEROCRD42023484490。
BACKGROUND: Cardiometabolic diseases cover a spectrum of interrelated conditions linked to metabolic dysfunctions and/or cardiovascular disorders, including systemic arterial hypertension, diabetes mellitus, dyslipidemia, and obesity. Cocoa is a rich source of dietary polyphenols and has been associated with cardiovascular health benefits. However, beneficial effects of cocoa consumption and appropriate quantities in decreasing cardiometabolic risk factors have yet to be established. Therefore, we will conduct a systematic review and meta-analysis to examine the effects of cocoa consumption on cardiometabolic risk markers (total cholesterol, HDL, LDL, triglycerides, blood glucose, glycated hemoglobin, waist circumference, abdominal circumference, body mass index, systolic blood pressure and diastolic blood pressure) in adults with or without established cardiovascular risk factors.
METHODS: Our review will include all randomized controlled trials published in English, Portuguese and Spanish with no date of publication restrictions evaluating the effects of cocoa consumption on cardiometabolic risk markers selected from the databases MEDLINE (PubMed), LILACS, Cochrane, EMBASE, Web of Science and SciELO, and gray literature. Eligible studies must involve adults (age ≥18y), and the consumption of cocoa or dark chocolate (≥ 70% cocoa), include a control group and evaluate blood pressure, anthropometric measurements, and lipid or glycemic profiles. We will use risk-of-bias 2 (RoB2) tool to assess the risk of bias and the GRADE system to assess the strength of evidence. Statistical analyses will be performed using RStudio for Windows and R package meta.
CONCLUSIONS: This meta-analysis will summarize existing evidence on the effects of cocoa consumption on cardiometabolic health in adults. Better understanding the effects of cocoa consumption on anthropometric measurements, blood pressure, and lipid and glycemic profiles can provide valuable insights for health professionals to improve dietary recommendations regarding appropriate quantities.
BACKGROUND: Systematic Review Registration: PROSPERO CRD42023484490.