PDF(Pubmed)
Abstract：
Cardiovascular diseases (CVDs) are one of the main causes of mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role in improving cardiovascular health. Flavan-3-ols represent a subclass of (poly)phenols of great interest for their possible health benefits. In this review, we summarized the results of clinical studies on vascular outcomes of flavan-3-ol supplementation and we focused on the role of the microbiota in CVD. Clinical trials included in this review showed that supplementation with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure and improves endothelial function. Studies on catechins from green tea demonstrated better results when involving healthy individuals. From a mechanistic point of view, emerging evidence suggests that microbial metabolites may play a role in the observed effects. Their function extends beyond the previous belief of ROS scavenging activity and encompasses a direct impact on gene expression and protein function. Although flavan-3-ols appear to have effects on cardiovascular health, further studies are needed to clarify and confirm these potential benefits and the rising evidence of the potential involvement of the microbiota.
摘要：
心血管疾病（CVDs）是世界范围内死亡率和发病率的主要原因之一。富含植物衍生化合物如(多)酚的健康饮食似乎在改善心血管健康方面具有关键作用。黄烷-3-醇代表因其可能的健康益处而引起极大兴趣的(多)酚的亚类。在这次审查中,我们总结了黄烷-3-醇补充的血管结局的临床研究结果,并关注了微生物群在CVD中的作用.本综述中包含的临床试验表明，补充主要来自可可产品的黄烷-3-醇可显著降低血压并改善内皮功能。对绿茶中儿茶素的研究表明，当涉及健康个体时，效果更好。从机械的角度来看，新出现的证据表明，微生物代谢物可能在观察到的影响中发挥作用。它们的功能超出了ROS清除活性的先前信念，并包括对基因表达和蛋白质功能的直接影响。虽然黄烷-3-醇似乎对心血管健康有影响，需要进一步的研究来澄清和确认这些潜在的益处以及越来越多的微生物群参与的证据.
