未经证实:胰岛素抵抗可以通过甘油三酯-葡萄糖指数(TyG)来评估,一个简单的,低成本,和易于应用的方法。
UNASSIGNED:评估TyG指数对心血管风险的预测能力,并确定其在心血管代谢风险人群中的临界点。
未经评估:对264名处于心血管代谢风险的个体进行的横断面研究(54.9%为女性,年龄:43.1±16.3岁)。人口统计,人体测量学,临床实验室,收集生活方式数据。使用公式Ln[空腹甘油三酯(mg/dL)X空腹血浆葡萄糖(mg(dL)/2]测定TyG指数。通过Framingham风险评分(FRS)评估十年心血管风险。受试者工作特征曲线(ROC)用于定义TyG指数的截止点,并通过泊松回归检验其相关性。
UNASSIGNED:ROC曲线分析表明曲线下面积为0.678(95%CI=0.618-0.734;p<0.001),截止值为9.04(灵敏度=62.5%,特异性=66.7%,阳性预测值=29.4%,阴性预测值=88.9%)。升高的TyG值(≥9.04)与心脏代谢危险因素(总胆固醇,LDL,VLDL,尿酸,丙氨酸氨基转移酶,天冬氨酸转氨酶,腰臀比,收缩压,HOMA-IR,吸烟,代谢综合征,糖尿病,和肝脂肪变性)。在对混杂因素进行调整后,高TyG的个体在FRS的中/高风险患病率中增加了69%(RP=1.69;95CI=1.03-2.78),与那些低TyG相比。
UNASSIGNED:通过FRS评估,TyG指数在十年内显示出良好的心血管风险预测能力。
UNASSIGNED: Insulin resistance can be assessed by the Triglyceride-Glucose Index (TyG), a simple, low-cost, and easy-to-apply method.
UNASSIGNED: To assess the predictive capacity of the TyG index about cardiovascular risk and identify its cutoff point in a population at cardiometabolic risk.
UNASSIGNED: Cross-sectional study with 264 individuals at cardiometabolic risk (54.9% women, age: 43.1 ± 16.3 years). Demographic, anthropometric, clinical-laboratory, and lifestyle data were collected. The TyG index was determined using the formula Ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg (dL)/2]. The ten-year cardiovascular risk was assessed by the Framingham risk score (FRS). The receiver operating characteristic curve (ROC) was used to define the cutoff point for the TyG index, and the associations were tested by Poisson regression.
UNASSIGNED: ROC curve analysis indicated an area under the curve of 0.678 (95% CI = 0.618-0.734; p < 0.001), with a cutoff of 9.04 (sensitivity = 62.5%, specificity = 66.7%, positive predictive value = 29.4% and negative predictive value = 88.9%). Elevated TyG values (≥9.04) were positively associated with cardiometabolic risk factors (total cholesterol, LDL, VLDL, uric acid, alanine aminotransferase, aspartate aminotransferase, waist-hip ratio, systolic blood pressure, HOMA-IR, smoking, metabolic syndrome, diabetes, and hepatic steatosis). After adjustment for confounding factors, individuals with high TyG showed an increase of 69% (RP = 1.69; 95%CI = 1.03-2.78) in the prevalence of intermediate/high risk by FRS, compared to those with low TyG.
UNASSIGNED: The TyG index showed a good predictive capacity for cardiovascular risk in ten years assessed by the FRS.