PDF(Pubmed)
Abstract：
BACKGROUND: The clinical epidemiology of hospitalized COVID-19 patients has never been described before in Lebanon. Moreover, the hospital admission and PCR positivity rates have not been assessed and compared yet.
OBJECTIVE: To describe the characteristics and outcomes of hospitalized patients with coronavirus induced disease 2019 (COVID-19) in Lebanon and identify risk factors for severe disease or death.
METHODS: This is a retrospective mono-center cohort study in which we used patients\' files to extract and analyse data on demographic and clinical characteristics, as well as mortality. Moreover, we tracked the pandemic by recording the daily total and ICU inpatient census and the PCR positivity rate for admitted and outpatients.
RESULTS: Although the total admission rate increased from September to April, the ICU census switched this trend in December to stabilize at an average of around 10 patients/day until April. The case fatality rate was 19% for the 902 hospitalized patients, of which the majority (80%) had severe COVID-19. The severity odds ratio is significantly decreased in immunosuppressed cases (OR, 0.18; CI, 0.05-0.67; p=0.011). Additionally, the odds of COVID-19 related death are significantly greater if consolidations are found in the chest computed tomography (CT) scan (OR, 12; CI, 2.63-55.08; p=0.0013).
CONCLUSIONS: Consolidations in the lungs significantly increase the COVID-19 death risk. Risk factors identification is important to improve patients\' management and vaccination strategies. In addition, hospital statistics are good indicators of a pandemic\'s track.
OBJECTIVE: To describe the characteristics and outcomes of hospitalized patients with coronavirus induced disease 2019 (COVID-19) in Lebanon and identify risk factors for severe disease or death.
METHODS: This is a retrospective mono-center cohort study in which we used patients\' files to extract and analyse data on demographic and clinical characteristics, as well as mortality. Moreover, we tracked the pandemic by recording the daily total and ICU inpatient census and the PCR positivity rate for admitted and outpatients.
RESULTS: Although the total admission rate increased from September to April, the ICU census switched this trend in December to stabilize at an average of around 10 patients/day until April. The case fatality rate was 19% for the 902 hospitalized patients, of which the majority (80%) had severe COVID-19. The severity odds ratio is significantly decreased in immunosuppressed cases (OR, 0.18; CI, 0.05-0.67; p=0.011). Additionally, the odds of COVID-19 related death are significantly greater if consolidations are found in the chest computed tomography (CT) scan (OR, 12; CI, 2.63-55.08; p=0.0013).
CONCLUSIONS: Consolidations in the lungs significantly increase the COVID-19 death risk. Risk factors identification is important to improve patients\' management and vaccination strategies. In addition, hospital statistics are good indicators of a pandemic\'s track.
摘要：
背景：以前从未在黎巴嫩描述过住院COVID-19患者的临床流行病学。此外，入院率和PCR阳性率尚未进行评估和比较.
目的：描述黎巴嫩2019年冠状病毒诱发疾病（COVID-19）住院患者的特征和结局，并确定严重疾病或死亡的危险因素。
方法：这是一项回顾性单中心队列研究，我们使用患者档案来提取和分析有关人口统计学和临床特征的数据，以及死亡率。此外，我们通过记录每天的总和ICU住院患者普查以及入院和门诊患者的PCR阳性率来追踪大流行.
结果：尽管从9月到4月的总入院率有所增加，ICU人口普查在12月改变了这一趋势，稳定在平均每天约10名患者，直到4月。902名住院患者的病死率为19%，其中大多数（80%）患有严重的COVID-19。免疫抑制病例的严重程度比值比显著降低(OR，0.18；CI，0.05-0.67；p=0.011）。此外,如果在胸部计算机断层扫描(CT)扫描中发现合并，则COVID-19相关死亡的可能性显著更大(OR，12；CI，2.63-55.08；p=0.0013）。
结论：肺部巩固显着增加COVID-19死亡风险。危险因素识别对于改善患者管理和疫苗接种策略非常重要。此外,医院统计数据是大流行轨迹的良好指标。
目的：描述黎巴嫩2019年冠状病毒诱发疾病（COVID-19）住院患者的特征和结局，并确定严重疾病或死亡的危险因素。
方法：这是一项回顾性单中心队列研究，我们使用患者档案来提取和分析有关人口统计学和临床特征的数据，以及死亡率。此外，我们通过记录每天的总和ICU住院患者普查以及入院和门诊患者的PCR阳性率来追踪大流行.
结果：尽管从9月到4月的总入院率有所增加，ICU人口普查在12月改变了这一趋势，稳定在平均每天约10名患者，直到4月。902名住院患者的病死率为19%，其中大多数（80%）患有严重的COVID-19。免疫抑制病例的严重程度比值比显著降低(OR，0.18；CI，0.05-0.67；p=0.011）。此外,如果在胸部计算机断层扫描(CT)扫描中发现合并，则COVID-19相关死亡的可能性显著更大(OR，12；CI，2.63-55.08；p=0.0013）。
结论：肺部巩固显着增加COVID-19死亡风险。危险因素识别对于改善患者管理和疫苗接种策略非常重要。此外,医院统计数据是大流行轨迹的良好指标。
