细胞角蛋白18(CK18),中间丝家族的I型细胞角蛋白,几十年来一直与癌症患者的预后有关。然而,其在预测乳腺癌临床结局中的确切作用仍存在争议。全面探讨CK18在乳腺癌中的预后价值。我们进行了一项系统的荟萃分析,以探讨CK18表达与总生存期之间的关系.文献收集是通过检索电子数据库Pubmed,科克伦图书馆,WebofScience,EMBASE,和OVID完全(截至2017年1月1日)。我们的分析中纳入了9项相关研究,其中4857例评估了CK18高表达与乳腺癌患者预后之间的关系。结果表明,CK18的高水平表达与乳腺癌患者的总体生存率显着相关。使用血清检测CK18表达的报告预测了乳腺癌的不良预后(HR=1.24,95CI:1.11-1.38,P<0.0001)。而使用组织作为标本的研究表明相反的结果(HR=0.71,95CI:0.60-0.84,P<0.00001)。此外,CK18的过度表达与乳腺癌的晚期临床病理参数高度相关,如孕激素受体,人表皮生长因子受体2,肿瘤大小,肿瘤分期,节点状态,和肿瘤等级。一起来看,本研究表明,CK18可能作为预测乳腺癌临床病理特征和预后的新型生物标志物.
Cytokeratin 18 (
CK18), a type I cytokeratin of the intermediate filament family, has been associated with the prognosis of cancer patients for decades. However, its exact role in predicting the clinical outcome of breast cancer remains controversial. To comprehensively investigated the prognostic value of CK18 in breast cancer, a systematically meta-analysis was conducted to explore the association between
CK18 expression and overall survival. Literature collection was conducted by retrieving electronic databases Pubmed, Cochrane Library, Web of Science, EMBASE, and OVID completely (up to January 1, 2017). Nine relevant studies with 4857 cases assessing the relationship between
CK18 high expression and the outcome of breast cancer patients were enrolled in our analysis. The results indicated that the high level of
CK18 expression was significantly associated with overall survival of breast cancer patients via a specimen-depended manner. Reports which used serum to detect the expression of
CK18 predicted a poor outcome of breast cancer (HR = 1.24, 95%CI: 1.11-1.38, P<0.0001), while studies which used tissue as specimen indicated a reverse result (HR = 0.71, 95%CI: 0.60-0.84, P<0.00001). Moreover, overexpression of CK18 was highly relevant to advanced clinicopathological parameters of breast cancer, such as progesterone receptor, human epidermal growth factor receptor-2, tumor size, tumor stage, nodal status, and tumor grade. Taken together, the present study demonstrated that CK18 might be served as a novel biomarker to predict clinicopathological features and the outcome of breast cancer.