Abstract:
Malignant odontogenic neoplasms are extremely challenging to study due to their rarity and variable clinical presentations. Ameloblastic carcinoma (AC) is one such odontogenic tumor which has been the subject of controversy, in part because of its scarcity, complicated by confusion in terminology along with complexity in classification. Histologic features of AC resemble tumor cells of ameloblastoma but exhibit cellular atypia. Surgical resection for this kind of lesion, leaving at least a 2 cm free margin coupled with neoadjuvant radiotherapy, might prove fruitful results. The current paper reports a case of an extraosseous variant of AC which posed a diagnostic challenge due to variable presentations histopathologically, suggesting the need for evidence-based case studies and molecular workup for a better therapeutic and prognostic insight.
摘要:
恶性牙源性肿瘤由于其稀有性和多变的临床表现而极具挑战性。成釉细胞癌(AC)是一种牙源性肿瘤,一直是争议的主题,部分原因是它的稀缺性,由于术语的混淆和分类的复杂性而变得复杂。AC的组织学特征类似成釉细胞瘤的肿瘤细胞,但表现出细胞异型性。这种病变的手术切除,留下至少2厘米的自由边缘,再加上新辅助放疗,可能会取得丰硕的成果。本论文报道了一例AC的骨外变体,由于组织病理学上的不同表现而提出了诊断挑战,提示需要进行循证案例研究和分子检查,以获得更好的治疗和预后洞察.