在中国,中药(TCM)在治疗COVID-19中起着至关重要的作用。但其有效性尚未在世界范围内得到广泛认识/认可。我们进行了系统评价和荟萃分析,以探讨中医药治疗COVID-19的临床疗效。我们从PubMed获得了COVID-19和中药的数据,MEDLINE,WebofScience和其他数据库,并从2020年1月1日至2022年1月26日进行搜索,以确定不受语言限制的随机对照试验(RCT)。该综述包括26项随机临床试验,包括2981名患者。中医药联合常规治疗在许多方面比单纯常规治疗更有效,包括有效率的增加[OR=2.47,95CI(1.85,3.30),P<0.00001],发热消失率[OR=3.68,95CI(1.95,6.96),P<0.0001],疲劳消失率[OR=3.15,95CI(1.60,6.21),P=0.0009],咳嗽消失率[OR=2.89,95CI(1.84,4.54),P<0.00001],排痰消失率[OR=5.94,95CI(1.98,17.84),P=0.001],呼吸短促消失率[OR=2.57,95CI(1.13,5.80),P=0.02],CT图像改善率[OR=2.43,95CI(1.86,3.16),P<0.00001],住院时间缩短[MD=-3.16,95CI(-3.75,-2.56),P<0.00001],和恶化率[OR=0.49,95CI(0.29,0.83),P=0.007]。这项荟萃分析的结果表明,中医可以有效缓解症状,促进患者康复,降低患者发展为严重疾病的比率,并降低恶化率。
Traditional Chinese Medicine (TCM) has played crucial roles in treating COVID-19 in China. But its effectiveness has not yet been widely realized/recognized over the world. We performed a systematic review and meta-analysis to investigate the clinical efficacy of TCM medicine in the treatment for COVID-19. We obtained the data of COVID-19 and traditional Chinese medicine from PubMed, MEDLINE, Web of Science and other databases, and searched from January 1, 2020 to January 26, 2022 to determine the randomized controlled trials (RCTs) without language restrictions. The review includes 26 randomized clinical trials including 2981 patients. The treatment of COVID-19 by TCM combined with conventional treatment is more effective than by pure conventional treatment in many aspects, including increasing of the effective rate [OR = 2.47, 95%CI (1.85, 3.30), P < 0.00001], fever disappearance rate [OR = 3.68, 95%CI (1.95, 6.96), P < 0.0001], fatigue disappearance rate [OR = 3.15, 95%CI (1.60, 6.21), P = 0.0009], cough disappearance rate [OR = 2.89, 95%CI (1.84, 4.54), P < 0.00001], expectoration disappearance rate [OR = 5.94, 95%CI (1.98, 17.84), P = 0.001], disappearance rate of shortness of breath [OR = 2.57, 95%CI (1.13, 5.80), P = 0.02], improvement rate of CT image [OR = 2.43, 95%CI (1.86, 3.16), P < 0.00001], and reduction of the hospitalization time [MD = -3.16, 95%CI (-3.75, -2.56), P < 0.00001], and deterioration rate [OR = 0.49, 95%CI (0.29, 0.83), P = 0.007]. The findings of this meta-analysis suggest that TCM can effectively relieve symptoms, boosted patients\' recovery, cut the rate of patients developing into severe conditions, and reduce the deterioration rate.