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Abstract：
Clinical studies have shown that renal injury in Corona Virus Disease 2019 (COVID-19) patients has been a real concern, which is associated with high mortality and an inflammation/apoptosis-related causality. Effective target therapy for renal injury has yet been developed. Besides, potential anti-COVID-19 medicines have also been reported to cause adverse side effects to kidney. Chinese Herbal Medicine (CHM), however, has rich experience in treating renal injury and has successfully applied in China in the battle of COVID-19. Nevertheless, the molecular mechanisms of CHM treatment are still unclear. In this study, we searched prescriptions in the treatment of renal injury extensively and the potential mechanisms to treat COVID-19 related renal injury were investigated. The association rules analysis showed that the core herbs includes Huang Qi, Fu Ling, Bai Zhu, Di Huang, Shan Yao. TCM herbs regulate core pathways, such as AGE-RAGE, PI3K-AKT, TNF and apoptosis pathway, etc. The ingredients (quercetin, formononetin, kaempferol, etc.,) from core herbs could modulate targets (PTGS2 (COX2), PTGS1 (COX1), IL6, CASP3, NOS2, and TNF, etc.), and thereby prevent the pharmacological and non-pharmacological renal injury comparable to that from COVID-19 infection. This study provides therapeutic potentials of CHM to combat COVID-19 related renal injury to reduce complications and mortality.
摘要：
临床研究表明，2019年冠状病毒病（COVID-19）患者的肾损伤一直是一个真正的问题，这与高死亡率和炎症/凋亡相关的因果关系有关。目前还开发了针对肾损伤的有效靶向治疗。此外,据报道，潜在的抗COVID-19药物也会对肾脏造成不良副作用。中草药（CHM），然而,在治疗肾损伤方面具有丰富的经验，并在中国的COVID-19战斗中成功应用。然而，CHM治疗的分子机制尚不清楚.在这项研究中,我们广泛检索了治疗肾损伤的处方,并研究了治疗COVID-19相关肾损伤的潜在机制.关联规则分析表明，核心草药包括黄琦，傅玲,白竹,黄迪,山瑶。中草药调节核心途径，比如年龄-愤怒，PI3K-AKT,TNF与细胞凋亡通路,等。成分(槲皮素，福蒙素,山奈酚,等。,)来自核心草药可以调节靶标(PTGS2(COX2)，PTGS1(COX1),IL6、CASP3、NOS2和TNF，等。),从而预防与COVID-19感染相当的药理和非药理肾损伤。这项研究提供了CHM对抗COVID-19相关肾损伤以减少并发症和死亡率的治疗潜力。
