关键词： 11β-HSD, 11β-hydroxysteroid dehydrogenase 3CLpro, 3-chymotrypsin-like protease ACE2, Angiotensin converting enzyme 2 ADMET, absorption distribution metabolism excretion and toxicity ARDS, acute respiratory distress syndrome CHM, Chinese herbal medicine CNS, central nervous system COVID-19, Coronavirus Disease 2019 CTD, C-terminal domain Experimental and computational evidences Glycyrrhizin HMGB1, high-mobility-group box1 IL, Interleukin INF-γ, interferon-γ KEGG, Kyoto Encyclopedia of Genes and Genomes MD, molecular dynamics MERS, Middle East respiratory syndrome MM/GBSA, Molecular Mechanics/Generalized Born Surface Area MM/PBSA, Molecular Mechanics Poisson-Boltzmann Surface Area MR, mineralocorticoid receptor Molecular docking interactions NO, nitric oxide NTD, N-terminal domain ORF, open reading frame PLpro, papain-like protease RBD, receptor-binding domain RMSD, Root mean square deviation RMSF, Root mean square fluctuation ROS, reactive oxygen species RSV, respiratory syncytial virus RTC, replication-transcription complex RdRp, RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus-2 SI, Selectivity index TCM, Traditional Chinese Medicine TLR, Toll-like receptor TNF-α, Tumor necrosis factor α Traditional Chinese medicine nsp, non-structural protein

来  源：   DOI：10.1016/j.molstruc.2022.134642   PDF(Pubmed)

Abstract：
COVID-19 is the most devastating disease in recent times affecting most people globally. The higher rate of transmissibility and mutations of SARS-CoV-2 along with the lack of potential therapeutics has made it a global crisis. Potential molecules from natural sources could be a fruitful remedy to combat COVID-19. This systematic review highlights the detailed therapeutic implication of naturally occurring glycyrrhizin and its related derivatives against COVID-19. Glycyrrhizin has already been established for blocking different biomolecular targets related to the SARS-CoV-2 replication cycle. In this article, several experimental and theoretical evidences of glycyrrhizin and related derivatives have been discussed in detail to evaluate their potential as a promising therapeutic strategy against COVID-19. Moreover, the implication of glycyrrhizin in traditional Chinese medicines for alleviating the symptoms of COVID-19 has been reviewed. The potential role of glycyrrhizin and related compounds in affecting various stages of the SARS-CoV-2 life cycle has also been discussed in detail. Derivatization of glycyrrhizin for designing potential lead compounds along with combination therapy with other anti-SARS-CoV-2 agents followed by extensive evaluation may assist in the formulation of novel anti-coronaviral therapy for better treatment to combat COVID-19.
摘要：
COVID-19是近年来影响全球大多数人的最具破坏性的疾病。SARS-CoV-2的更高的传播率和突变率以及缺乏潜在的治疗方法使其成为全球危机。来自天然来源的潜在分子可能是对抗COVID-19的有效补救措施。本系统综述强调了天然存在的甘草酸及其相关衍生物对COVID-19的详细治疗意义。甘草甜素已经被确定用于阻断与SARS-CoV-2复制周期相关的不同生物分子靶标。在这篇文章中,已经详细讨论了甘草酸及其相关衍生物的一些实验和理论证据，以评估其作为抗COVID-19的有希望的治疗策略的潜力。此外，综述了中药中甘草酸对减轻COVID-19症状的作用。还详细讨论了甘草甜素和相关化合物在影响SARS-CoV-2生命周期的各个阶段中的潜在作用。甘草酸的衍生化用于设计潜在的先导化合物，以及与其他抗SARS-CoV-2药物的联合疗法，然后进行广泛的评估，可能有助于制定新型抗冠状病毒疗法，以更好地治疗COVID-19。
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