■艾滋病毒患者在医疗保健中心的持久性暴露了他们对各种进出医院环境的各种医院微生物的弱免疫力。细菌感染的发生率,包括尿路感染,与CD4+T细胞呈负相关。尿路感染(UTI)是HIV患者的临床问题之一。关于病毒载量之间关系的公开数据很少,CD4+水平,和UTI。本研究旨在评估HIV患者中病毒载量与CD4与细菌UTI之间的关系。
■横断面研究是在WolaitaSodo镇健康中心ART诊所进行的。使用预先设计的问卷收集社会人口统计数据。回顾了患者的图表,以收集当前的CD4和病毒载量。将尿液标本接种在血琼脂上,半胱氨酸乳糖电解质缺乏(CLED)琼脂,和MacConkey琼脂,并使用各种生化方法最终鉴定了细菌种类。使用标准微生物试验进行抗菌敏感性试验。采用双变量和多变量分析来描述变量对之间的关联,并检查自变量和因变量之间的关系。
■在这项研究中,尿路感染(UTI)的总患病率为13.7%.大肠杆菌,金黄色葡萄球菌,铜绿假单胞菌,腐生葡萄球菌,变形杆菌,肺炎克雷伯菌是本研究中检测到的细菌性尿路病原菌。大肠杆菌(45.7%)是主要分离株,其次是金黄色葡萄球菌(14.3%)。CD4+计数与尿路感染呈正相关(r=0.288p>0.01),而病毒载量与尿路感染呈负相关,且具有统计学意义(p<0.01)。大肠杆菌耐药率为94%,75%,69%的环丙沙星,诺氟沙星,还有头孢吡肟,分别。这项研究表明,大肠杆菌对阿莫西林-克拉维酸和四环素表现出94%和75%的耐药性,分别。肺炎克雷伯菌对阿莫西林-克拉维酸表现出完全抗性(100%),四环素,和甲氧苄啶-磺胺甲恶唑,同时显示对环丙沙星和呋喃妥因100%的敏感性。在本研究中,发现多药耐药(MDR)的程度为80%。CD4+计数,抗逆转录病毒疗法(ART)药物的组合,住院史是尿路感染的危险因素。
■在当前的研究中,在接受ART治疗后的HIV感染者中,尿路感染是一个重要的健康问题.HIV患者尿路感染的发生可能受多种因素的影响,需要进一步研究。CD4+计数与UTI患病率呈正相关,而病毒载量呈负相关。CD4+计数,艺术的结合,住院史是UTI的独立危险因素。MDR细菌病原体的患病率明显较高。因此,HIV患者的UTI治疗应根据抗菌药物敏感性试验结果进行.
UNASSIGNED: The permanence of HIV patients in healthcare provision centers exposes their weak immunity to various nosocomial microorganisms that migrate into and out of the hospital environment. The incidence of bacterial infections, including urinary tract infection, was inversely correlated with CD4+ T cells. Urinary tract infection (UTI) is one of the clinical problems among HIV patients. There was scarcity of published data on the relationship between viral load, CD4+ level, and UTI. This study aimed to assess the relationship between viral load and CD4 with bacterial UTI among HIV patients.
UNASSIGNED: The cross-sectional study was conducted in the Wolaita Sodo Town Health Center ART clinic. The socio-demographic data were collected using a pre-designed questionnaire. Patients\' charts were reviewed to collect the current CD4 and viral load. Urine specimens were inoculated on blood agar, cysteine lactose electrolyte deficient (CLED) agar, and MacConkey agar, and bacterial species were finally identified using various biochemical methods. Antimicrobial sensitivity testing was conducted using standard microbiological tests. Bivariate and multivariate analyses were employed to describe the association between pairs of variables and to examine the relationship between independent variables and dependent variables.
UNASSIGNED: In this study, the overall prevalence of urinary tract infection (UTI) was 13.7%. Escherichia coli, Staphylococcus aureus, Pseudomonas aeroginosa, Staphylococcus saprophyticus, Proteus mirabilis, and Klebsiella pneumoniae were bacterial uropathogens detected in this study. E.coli (45.7%) was the predominant isolate followed by S. aureus (14.3%). Positive correlation between CD4+ count and urinary tract infection was detected and found statistically significant (r = 0.288 p > 0.01), whereas the viral load and urinary tract infection negatively correlated and showed statistically significant association (p < 0.01). The resistance rate of E.coli was 94%, 75%, and 69% to ciprofloxacin, norfloxacin, and cefepime, respectively. This study revealed that E.coli exhibited 94% and 75% resistance to amoxicillin-clavulanic acid and tetracycline, respectively. K. pneumoniae demonstrated complete resistance (100%) to amoxicillin-clavulanic acid, tetracycline, and trimethoprim-sulfamethoxazole, while showing 100% susceptibility to ciprofloxacin and nitrofurantoin. In the present study, the magnitude of the multi-drug resistance (MDR) was found to be 80%. CD4+ count, combination of antiretroviral therapy (ART) drugs, and a history of hospitalization were risk factors for urinary tract infection.
UNASSIGNED: In the current study, urinary tract infection emerged as a significant health concern among people living with HIV following their ART. The occurrence of urinary tract infection among HIV patients could be influenced by multifactorial factors that require further study. The CD4+ count was positively correlated with the prevalence of UTI, whereas the viral load was negatively correlated. The CD4+ count, combination of ART, and history of hospitalization were independent risk factors for UTI. The prevalence of MDR bacterial pathogens were notably high. Therefore, the treatment of UTI in HIV patients should be prescribed based on antibacterial susceptibility testing results.