PDF(Pubmed)
Abstract：
UNASSIGNED: Combating human immunodeficiency virus/acquired immunodeficiency syndrome epidemic has been possible due to advances in prevention strategies and Antiretroviral therapy (ART). Optimal adherence to ART is a major factor in achieving the desired immunological, virological, and patient well-being outcomes. Several socio-demographic, patient, treatment, and health-care system-related factors influence nonadherent behavior to ART.
UNASSIGNED: This study was planned to assess (1) ART adherence level, (2) factors and reasons associated with nonadherence, and (3) impact of suboptimal adherence on treatment outcomes.
UNASSIGNED: This was a cross-sectional analytical study of 300 patients in a tertiary care hospital in Puducherry, India.
UNASSIGNED: Random sampling was used to collect data from patient treatment cards and a predesigned structured questionnaire. The pill count method was used to calculate adherence level.
UNASSIGNED: Nonadherence was chosen as a dependent variable and factors affecting adherence were chosen as independent variables. Test for significance was carried out by Chi-square test and Fisher\'s exact test.
UNASSIGNED: Optimal adherence was seen in 68.3%. Factors significantly associated with nonadherence were lower education level, high prior CD4 count, irregular follow-up, missing doses in the past, and being late for pharmacy pill refills. Adherence was positively associated with mean increase in CD4 count over 6 months.
UNASSIGNED: In our study, the adherence rate is suboptimal which can lead to failure of ART. Nonadherence was associated with a decrease in CD4 count overtime. Most of the factors significantly affecting ART adherence were patient behavior related. These factors can be used for target intervention during reinforcement adherence counseling.
UNASSIGNED: This study was planned to assess (1) ART adherence level, (2) factors and reasons associated with nonadherence, and (3) impact of suboptimal adherence on treatment outcomes.
UNASSIGNED: This was a cross-sectional analytical study of 300 patients in a tertiary care hospital in Puducherry, India.
UNASSIGNED: Random sampling was used to collect data from patient treatment cards and a predesigned structured questionnaire. The pill count method was used to calculate adherence level.
UNASSIGNED: Nonadherence was chosen as a dependent variable and factors affecting adherence were chosen as independent variables. Test for significance was carried out by Chi-square test and Fisher\'s exact test.
UNASSIGNED: Optimal adherence was seen in 68.3%. Factors significantly associated with nonadherence were lower education level, high prior CD4 count, irregular follow-up, missing doses in the past, and being late for pharmacy pill refills. Adherence was positively associated with mean increase in CD4 count over 6 months.
UNASSIGNED: In our study, the adherence rate is suboptimal which can lead to failure of ART. Nonadherence was associated with a decrease in CD4 count overtime. Most of the factors significantly affecting ART adherence were patient behavior related. These factors can be used for target intervention during reinforcement adherence counseling.
摘要：
■由于预防策略和抗逆转录病毒疗法（ART）的进步，抗击人类免疫缺陷病毒/获得性免疫缺陷综合症的流行成为可能。对ART的最佳依从性是实现所需免疫学的主要因素，病毒学,和患者的福祉结果。几个社会人口，病人,治疗,和医疗保健系统相关因素影响ART的非粘附行为。
■这项研究计划评估(1)ART依从性水平，（2）与不遵守有关的因素和原因，和（3）次优依从性对治疗结果的影响。
■这是一项针对Puducherry三级医院300名患者的横断面分析研究，印度。
■随机抽样用于从患者治疗卡和预先设计的结构化问卷中收集数据。使用药丸计数方法来计算依从性水平。
■选择不依从性作为因变量，选择影响依从性的因素作为自变量。显著性检验采用卡方检验和Fisher精确检验。
■最佳粘附率为68.3%。与不依从性显著相关的因素是较低的教育水平，先前的CD4计数高，不定期随访，过去丢失的剂量，药房药丸续装迟到了。坚持与6个月内CD4计数的平均增加呈正相关。
■在我们的研究中，依从性次优，可能导致ART失败。非依从性与CD4计数的减少相关。影响ART依从性的因素大多与患者行为相关。这些因素可用于强化依从性咨询期间的目标干预。
■这项研究计划评估(1)ART依从性水平，（2）与不遵守有关的因素和原因，和（3）次优依从性对治疗结果的影响。
■这是一项针对Puducherry三级医院300名患者的横断面分析研究，印度。
■随机抽样用于从患者治疗卡和预先设计的结构化问卷中收集数据。使用药丸计数方法来计算依从性水平。
■选择不依从性作为因变量，选择影响依从性的因素作为自变量。显著性检验采用卡方检验和Fisher精确检验。
■最佳粘附率为68.3%。与不依从性显著相关的因素是较低的教育水平，先前的CD4计数高，不定期随访，过去丢失的剂量，药房药丸续装迟到了。坚持与6个月内CD4计数的平均增加呈正相关。
■在我们的研究中，依从性次优，可能导致ART失败。非依从性与CD4计数的减少相关。影响ART依从性的因素大多与患者行为相关。这些因素可用于强化依从性咨询期间的目标干预。
