背景:缺乏评估患者和医疗保健专业人员(HCP)对长效可注射(LAI)抗精神病药属性的偏好的研究。
方法:对医生进行了调查,护士,以及至少有两次使用TV-46000的患者,TV-46000是一种用于治疗精神分裂症的研究性皮下LAI抗精神病药,作为SHINE研究的一部分(NCT03893825)。调查主题包括对管理途径的偏好,潜在的LAI给药间隔(每周一次,一个月两次,每月一次[q1m],每2个月[q2m]),注射位置,易用性,注射器类型,针头长度,需要重建。
结果:患者(n=63)的平均(SD)年龄为35.6(9.6)岁,诊断年龄为18(10)岁,大部分为男性(75%)。共有49名HCPs:24名医生和25名护士。患者被评为“短针”(68%),a“选择[q1m或q2m]给药间隔”(59%),和“注射而不是口服片剂”(59%)是最重要的特征。HCP评级为“单次注射开始治疗”(61%),“灵活的给药间隔”(84%),和“注射而不是口服片剂”(59%)是最重要的特征。62%的患者和84%的HCP将皮下注射评为“易于[接受/给药]”。在皮下注射和肌肉注射之间进行选择时,65%的HCPs首选皮下注射,57%的患者首选肌肉注射。对大多数HCP来说,有四种剂量强度选择(78%)是很重要的,预填充注射器(96%),并且不需要重建(90%)。
结论:患者有一系列的反应,在某些问题上,患者和HCP的偏好有所不同。总之,这表明为患者提供一系列选择的重要性,以及患者-HCP讨论LAI治疗偏好的重要性.
几种治疗精神分裂症的药物可作为长效注射剂使用。这些药物的一个优点是患者不需要每天服用药丸。在这项研究中,病人,医生,和护士被问及他们更喜欢什么药物特征。问题主题类似于以下内容:“应该多久服用一次?”;“您更喜欢哪种分娩方式?”;“应该在身体的哪个位置注射?”;“使用起来有多容易?”;“您喜欢什么物理特性?”;和“准备步骤重要吗?”患者认为能够每月或每隔一个月注射一次是最重要的特征之一(59%)。患者还喜欢短针(68%)和注射而不是口服药丸(59%)。医生和护士回答说,开始治疗需要一次注射(61%)。他们还喜欢选择药物的给药频率(84%),注射而不是口服药丸(59%)。对于大多数患者(62%)和医生和护士(84%)来说,注射“容易[获得/给予]”。大多数医生和护士(65%)喜欢在皮下注射。大多数患者(57%)喜欢向肌肉注射。总的来说,患者和医生/护士在大多数主题上达成一致。有,然而,一系列患者反应;因此,对于病人、医生和护士来说,谈论可用的治疗方案是很重要的。每个患者可以有自己的偏好。
Studies evaluating patient and healthcare professional (HCP) preferences regarding long-acting injectable (LAI) antipsychotic agent attributes are lacking.
Surveys were administered to physicians, nurses, and patients who had at least two experiences with TV-46000, an investigational subcutaneous LAI antipsychotic agent for the treatment of schizophrenia, as part of the SHINE study (NCT03893825). Survey topics included preferences for route of administration, potential LAI dosing intervals (once-weekly, twice a month, once a month [q1m], every 2 months [q2m]), injection location, ease of use, syringe type, needle length, and need for reconstitution.
Patients (n = 63) had a mean (SD) age of 35.6 (9.6) years, age at diagnosis of 18 (10) years, and were mostly male (75%). There were 49 HCPs: 24 physicians and 25 nurses. Patients rated \"a short needle\" (68%), a \"choice of [q1m or q2m] dosing interval\" (59%), and \"injection instead of oral tablet\" (59%) as the most important features. HCPs rated \"single injection to initiate treatment\" (61%), \"flexible dosing interval\" (84%), and \"injection instead of oral tablet\" (59%) as the most important features. Subcutaneous injections were rated \"easy to [receive/administer]\" by 62% of patients and 84% of HCPs. When choosing between subcutaneous injections and intramuscular injections, 65% of HCPs preferred subcutaneous injections and 57% of patients preferred intramuscular injections. It was important to most HCPs to have four dose strength options (78%), a prefilled syringe (96%), and no need for reconstitution (90%).
Patients had a range of responses, and on some issues patient and HCP preferences differed. Altogether, this suggests the importance of providing patients with a range of options and the importance of patient-HCP discussions on treatment preference for LAIs.
Several medications for treating schizophrenia are available as long-acting injections. One advantage of these medications is that patients do not need to take pills daily. In this study, patients, doctors, and nurses were asked what medication characteristics they preferred. Question topics were similar to the following: “how often should it be taken?”; “what method of delivery do you prefer?”; “where on the body should it be injected?”; “how easy was it to use?”; “what physical properties do you like?”; and “do preparation steps matter?” Patients thought that being able to be given monthly or every other month was one of the most important features of an injection (59%). Patients also liked a short needle (68%) and an injection instead of an oral pill (59%). Doctors and nurses responded that it was important to have a single injection to start treatment (61%). They also liked having options for how often the medication was given (84%), and an injection instead of an oral pill (59%). An injection was “easy to [get/give]” for most patients (62%) and doctors and nurses (84%). Most doctors and nurses (65%) liked giving injections under the skin. Most patients (57%) liked injections into the muscle. Overall, patients and doctors/nurses agreed on most topics. There were, however, a range of patient responses; therefore, it is important for patients and doctors and nurses to talk about the available treatment options. Each individual patient may have their own preferences.