■这项研究的主要目的是回顾与颅底骨髓炎(SBO)相关的临床参数,次要目的是在治疗开始后1个月和6个月研究它们与患者预后的关系。
■这是一项单中心再观察性研究。
■该研究于2018年1月至2022年12月在吉隆坡马来亚大学医学中心进行。
■诊断为SBO的年龄超过15岁的患者被纳入研究。临床参数,调查,并记录随访记录.使用多变量分析在治疗开始后1个月和6个月分析疾病结果。
■该研究确定了31名SBO患者,其中大多数是患有糖尿病和高血压等合并症的老年男性。耳痛和耳漏是最常见的症状,和计算机断层扫描用于诊断。铜绿假单胞菌是最常见的病原菌,和静脉内广谱抗微生物药物用于治疗所有患者。25%的患者需要手术干预,和潜在的缺血性心脏病,贫血,单神经麻痹与不良预后显著相关。体重指数较高且C反应蛋白升高的患者在治疗1个月和6个月后表现出较差的预后。分别。
■早期识别,及时治疗,更好地控制合并症,营养,和监测可以改善SBO结果并减少并发症。因此,随着SBO患病率的增加,应制定诊断标准或管理指南以指导最佳临床实践.
UNASSIGNED: The primary objective of this study is to review the clinical parameters associated with skull base osteomyelitis (SBO), with a secondary aim of studying their association with patient outcomes 1 and 6 months after treatment initiation.
UNASSIGNED: This is a single-center restrospective observational study.
UNASSIGNED: The study was conducted from January 2018 to December 2022 at the University Malaya Medical Center in Kuala Lumpur.
UNASSIGNED: Patients aged over 15 years with a diagnosis of SBO were included in the study. Clinical parameters, investigations, and follow-up records were recorded. The disease outcomes were analyzed at 1 and 6 months after treatment initiation using multivariable analyses.
UNASSIGNED: The study identified 31 patients with SBO, the majority of whom were elderly males with comorbidities such as diabetes and hypertension. Otalgia and otorrhea were the most common symptoms, and computed tomography scans were used for diagnosis. Pseudomonas aeruginosa was the most commonly identified pathogen, and intravenous broad-spectrum antimicrobials were used to treat all patients. Surgical intervention was required for 25% of patients, and underlying ischemic heart disease, anemia, and single nerve palsy were significantly associated with an unfavorable prognosis. Patients with higher body mass index and elevated C-reactive protein showed poorer outcomes after 1 and 6 months of treatment, respectively.
UNASSIGNED: Early recognition, prompt treatment, better control of comorbidities, nutrition, and monitoring can improve SBO outcomes and reduce complications. Therefore, as the prevalence of SBO increases, diagnostic criteria or management guidelines should be established to guide the best clinical practice.