PDF(Pubmed)
Abstract：
Skull base osteomyelitis is a rare and life-threatening infection of the skull base, commonly seen in elderly diabetic patients as a result of otogenic or paranasal infection. The diagnosis is based on a series of arguments, including a high clinical suspicion, imaging findings, negative biopsies for malignancy, and microbiological isolation. Complications, including abscess formation and vascular involvement, mandate a multidisciplinary treatment approach, primarily involving broad-spectrum antibiotics and surgical debridement, but the prognosis is usually poor. Herein, we describe the case of a 55-year-old male, who 15 years prior, underwent radiation therapy for nasopharyngeal carcinoma. He presented with an infection of the skull base with extensive bone erosion accompanied by an uncommon complication; an intra clival abscess. Despite aggressive antibiotic therapy, the patient ultimately succumbed to septic shock.
摘要：
颅底骨髓炎是一种罕见的威胁生命的颅底感染,常见于因耳源性或鼻旁感染引起的老年糖尿病患者。诊断是基于一系列的论点，包括高度的临床怀疑,影像学发现，恶性肿瘤活检阴性，和微生物分离。并发症,包括脓肿形成和血管受累，授权多学科治疗方法，主要涉及广谱抗生素和外科清创，但预后通常较差。在这里，我们描述了一个55岁男性的案例，15年前，接受鼻咽癌放射治疗。他表现为颅底感染，伴有广泛的骨侵蚀，并伴有罕见的并发症；斜坡内脓肿。尽管积极的抗生素治疗，患者最终死于感染性休克.
