目的:评估拉丁美洲幼儿门诊胃肠道(GI)诊所的肠-脑相互作用(DGBIs)障碍的相对频率和相关因素。
方法:在拉丁美洲五个国家(萨尔瓦多,墨西哥,哥伦比亚,Panamá,和尼加拉瓜)。来自门诊诊所的1个月4岁患者的父母根据罗马IV标准(QPGS-IV,西班牙语版本)。我们进行了描述性分析,双样本t检验和卡方检验,单变量分析,和逻辑回归来评估危险因素。
结果:我们收集了783名儿童的数据。总的来说,34.5%有DGBI。总的来说,功能性便秘(FC)是所有年龄段儿童中最常见的诊断(23.4%)(婴儿,16.1%,1-4岁,32.7%)。在婴儿中,第二常见的DGBI是反流(6.6%)和1~4岁和周期性呕吐综合征(4.1%).DGBI的诊断与DGBI家族史显著相关(比值比[OR]2.97,95%置信区间[CI]1.61-5.57,p=0.0001)。确定为黑人(OR2.25,95%CI1.28-3.92,p=0.0021)或混合种族(OR1.76,95%CI1.25-2.48,p=0.0006)的患者也与较高的DGBIs可能性显着相关。
结论:DGBIs是拉丁美洲儿科胃肠道诊所的常见诊断。总的来说,FC是最常见的DGBI。
OBJECTIVE: To assess the relative frequency and associated factors of disorders of gut-brain interaction (DGBIs) in outpatient gastrointestinal (GI) clinics in young children of Latin America.
METHODS: Cross-sectional study in 10 pediatric GI outpatient clinics (private and public) in five countries of Latin America (El Salvador, México, Colombia, Panamá, and Nicaragua). Parents of patients 1 month 4 years of age from outpatient clinics complete/d a diagnostic questionnaire for DGBIs per Rome IV criteria (QPGS-IV, Spanish version). We conducted descriptive analysis, two-sample t-tests and chi-square tests, univariate analyses, and logistic regression to evaluate risk factors.
RESULTS: We collected data from 783 children. In total, 34.5% had a DGBI. Overall, functional constipation (FC) was the most common diagnosis (23.4%) in children of all ages (infants, 16.1%, 1-4-years-old, 32.7%). In infants, the second most common DGBI was regurgitation (6.6%) and in 1-4-years-old and cyclic vomiting syndrome (4.1%). The diagnosis of a DGBI was significantly associated with a family history of DGBIs (odds ratio [OR] 2.97, 95% confidence interval [CI] 1.61-5.57, p = 0.0001). Patients who identified as black (OR 2.25, 95% CI 1.28-3.92, p = 0.0021) or mixed race (OR 1.76, 95% CI 1.25-2.48, p = 0.0006) were also significantly associated with a higher likelihood of DGBIs.
CONCLUSIONS: DGBIs are a common diagnosis in pediatric GI clinics of Latin America. Overall, FC was the most common DGBI.