PDF(Pubmed)
Abstract：
UNASSIGNED: Previous studies report an association between joint hypermobility (JH), as a hallmark of connective tissue disorder, and autonomic dysfunction, digestive problems, and irritable bowel syndrome. However, its association with functional constipation (FC) has not been evaluated. This study is run and implemented to justify this theme/topic.
UNASSIGNED: In this case-control study among 200 subjects, 100 were of FC according to the ROME III Criteria (case group) and each child was matched for age and gender with a healthy control that did not meet criteria for FC (control group). The demographic information and JH were assessed and compared in both groups, through a physical examination according to the Beighton score.
UNASSIGNED: A total of 200 children with a mean age of 6.2 ± 2.2 years constituted the statistical population. The prevalence of JH was assessed to establish the Beighton score (≥4 was considered JH). There was no significant difference in JH between children with and without FC, odds ratio (OR) 1.13 (95% confidence interval [CI]: 0.65-1.98, P = 0.669). There was no significant difference in terms of gender and age between the two groups (P = 0.887, P = 0.396, respectively). JH was not significantly associated with gender (P = 0.445) while significantly associated with age (P = 0.041). Furthermore, there was no significant association between JH and FC (P = 0.669). Following multivariate logistic regression analysis between the presence of JH as the dependent variable and the measured variables as the independent variables, only age had significant independent predictive values in the development of JH (P = 0.041, OR =0.88 [0.77-1]). The obtained adjusted OR in this study indicated that at each year age increase the JH risk decreased by 12%.
UNASSIGNED: Here, it is revealed that the relative frequency of JH in this age range, with and without FC, is not significantly different, and it is not significantly associated with gender while significantly associated with age.
UNASSIGNED: In this case-control study among 200 subjects, 100 were of FC according to the ROME III Criteria (case group) and each child was matched for age and gender with a healthy control that did not meet criteria for FC (control group). The demographic information and JH were assessed and compared in both groups, through a physical examination according to the Beighton score.
UNASSIGNED: A total of 200 children with a mean age of 6.2 ± 2.2 years constituted the statistical population. The prevalence of JH was assessed to establish the Beighton score (≥4 was considered JH). There was no significant difference in JH between children with and without FC, odds ratio (OR) 1.13 (95% confidence interval [CI]: 0.65-1.98, P = 0.669). There was no significant difference in terms of gender and age between the two groups (P = 0.887, P = 0.396, respectively). JH was not significantly associated with gender (P = 0.445) while significantly associated with age (P = 0.041). Furthermore, there was no significant association between JH and FC (P = 0.669). Following multivariate logistic regression analysis between the presence of JH as the dependent variable and the measured variables as the independent variables, only age had significant independent predictive values in the development of JH (P = 0.041, OR =0.88 [0.77-1]). The obtained adjusted OR in this study indicated that at each year age increase the JH risk decreased by 12%.
UNASSIGNED: Here, it is revealed that the relative frequency of JH in this age range, with and without FC, is not significantly different, and it is not significantly associated with gender while significantly associated with age.
摘要：
■先前的研究报告了关节过度活动(JH)之间的关联，作为结缔组织疾病的标志，和自主神经功能障碍,消化问题,肠易激综合征.然而,尚未评估其与功能性便秘（FC）的相关性。本研究的运行和实施是为了证明这个主题/主题。
■在这项200名受试者的病例对照研究中，根据ROMEIII标准（病例组），每个儿童的年龄和性别与不符合FC标准的健康对照（对照组）相匹配。评估并比较两组的人口统计信息和JH，根据Beighton分数进行体检。
■共有200名平均年龄为6.2±2.2岁的儿童构成了统计人群。评估JH的患病率以建立Beighton评分（≥4被认为是JH）。有和没有FC的儿童之间的JH没有显着差异，比值比（OR）1.13（95%置信区间[CI]：0.65-1.98，P=0.669）。两组患者性别、年龄差异无统计学意义(P=0.887,P=0.396)。JH与性别无显著相关性(P=0.445),而与年龄显著相关(P=0.041)。此外，JH与FC之间无显著相关性(P=0.669)。在JH作为因变量和测量变量作为自变量之间的多变量逻辑回归分析之后，仅年龄对JH的发生有显著的独立预测价值(P=0.041,OR=0.88[0.77-1]).在这项研究中获得的校正OR表明，在每年年龄增加时，JH风险降低了12％。
■这里，揭示了JH在这个年龄范围内的相对频率，有和没有FC，没有明显不同，它与性别没有显着相关，而与年龄显着相关。
■在这项200名受试者的病例对照研究中，根据ROMEIII标准（病例组），每个儿童的年龄和性别与不符合FC标准的健康对照（对照组）相匹配。评估并比较两组的人口统计信息和JH，根据Beighton分数进行体检。
■共有200名平均年龄为6.2±2.2岁的儿童构成了统计人群。评估JH的患病率以建立Beighton评分（≥4被认为是JH）。有和没有FC的儿童之间的JH没有显着差异，比值比（OR）1.13（95%置信区间[CI]：0.65-1.98，P=0.669）。两组患者性别、年龄差异无统计学意义(P=0.887,P=0.396)。JH与性别无显著相关性(P=0.445),而与年龄显著相关(P=0.041)。此外，JH与FC之间无显著相关性(P=0.669)。在JH作为因变量和测量变量作为自变量之间的多变量逻辑回归分析之后，仅年龄对JH的发生有显著的独立预测价值(P=0.041,OR=0.88[0.77-1]).在这项研究中获得的校正OR表明，在每年年龄增加时，JH风险降低了12％。
■这里，揭示了JH在这个年龄范围内的相对频率，有和没有FC，没有明显不同，它与性别没有显着相关，而与年龄显着相关。
