背景:肺炎克雷伯菌引起的化脓性肝脓肿(PLA)的严重程度各不相同,与PLA器官功能障碍发展的几个危险因素有关。然而,迄今为止,很少有研究探讨临床严重程度最常见的危险因素.
方法:我们在2013年2月至2022年12月期间对肺炎克雷伯菌引起的PLA患者进行了一项研究。使用逻辑回归分析,我们试图确定与血培养阳性相关的因素,感染性休克,和重症监护病房(ICU)入院。
结果:纳入200例患者后,我们发现降钙素原(PCT)水平升高(p=0.03),较高的葡萄糖水平(p=0.03),和较低的总胆固醇(TC)水平(p=0.01)与血液细菌培养阳性的可能性较高有关。此外,PCT水平升高(p=0.02)和TC水平降低(p<0.01)与感染性休克风险升高相关.此外,更高的PCT水平(p<0.01)与更高的ICU入住概率相关.
结论:在由肺炎克雷伯菌引起的PLA患者中,PCT,葡萄糖,发现TC水平与血培养阳性有关,感染性休克,ICU入院。
BACKGROUND: Pyogenic liver abscess (PLA) caused by Klebsiella pneumoniae can vary in severity, and several risk factors for the development of organ dysfunction in PLA have been implicated. However, few studies to date have explored the most common risk factors for clinical severity.
METHODS: We conducted a study on patients with PLA caused by Klebsiella pneumoniae between February 2013 and December 2022.Using logistic regression analysis, we sought to identify factors associated with positive blood culture, septic shock, and intensive care unit (ICU) admission.
RESULTS: After included 200 patients, we found that an elevated procalcitonin (PCT) level (p = 0.03), higher glucose level (p = 0.03), and lower total cholesterol (TC) level (p = 0.01) were associated with a higher likelihood of positive blood bacteriological culture. Additionally, an increased PCT level (p = 0.02) and lower TC level (p < 0.01) were associated with an elevated risk of septic shock. Furthermore, a higher PCT level (p < 0.01) was associated with a higher probability of ICU admission.
CONCLUSIONS: In patients with PLA caused by Klebsiella pneumoniae, the PCT, glucose, and TC levels were found to be associated with positive blood culture, septic shock, and ICU admission.