■血小板减少和严重疾病的不良预后相关。然而,尚未评估化脓性肝脓肿(PLA)中血小板减少症的临床意义。
■评价血小板减少症与PLA患者预后的关系。
■在同济医院住院的连续458例解放军成年患者(武汉,中国)在2011年10月至2021年6月期间被纳入这一横截面分析。在血小板减少组和非血小板减少组之间比较患者数据。多元逻辑回归,受试者工作特征(ROC)曲线和倾向评分匹配分析(PSM).
■在458名解放军患者中,94(20.5%)发生血小板减少症,19人(4.1%)发生感染性休克,14人(3.1%)入住重症监护病房,15人(3.3%)在住院期间死亡.血小板减少与休克独立相关(95CI=3.529-57.944,P<0.001),ICU入院(95CI=1.286-25.733,P=0.022),和死亡率(95CI=1.947-34.223,P=0.004)的多元回归分析。ROC分析显示血小板减少症可能是休克[ROC曲线下面积(AUC),0.8119;截止,92.50;P<0.0001],ICU入院(AUC,0.7484;截止,82.50;P<0.0015),和死亡率(AUC,0.7827;截止,122.50;P<0.002)。这些发现在分析PSM分析的86对患者中保持一致。
■血小板减少是PLA患者预后不良的独立危险因素,患者可能更容易出现不良后果。
UNASSIGNED: Thrombocytopenia and poor prognosis in severe conditions are associated. However, the clinical significance of thrombocytopenia in pyogenic liver abscess (PLA) has not been evaluated.
UNASSIGNED: To evaluate the association between thrombocytopenia and the prognosis of patients with PLA.
UNASSIGNED: A consecutive
case series of 458 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, China) between October 2011 and June 2021 was included in this cross-sectional analysis. Patient data were compared between the thrombocytopenia and non-thrombocytopenia groups. Multivariate logistic regression, receiver operating characteristic (ROC) curve and propensity score -matched analyses (PSM) were performed.
UNASSIGNED: Of the 458 patients with PLA, 94 (20.5%) developed thrombocytopenia, 19 (4.1%) developed septic shock, 14 (3.1%) were admitted to the ICU, and 15 (3.3%) died during hospitalization. Thrombocytopenia was independently associated with shock (95%CI = 3.529-57.944, P < 0.001), ICU admission (95%CI = 1.286-25.733, P = 0.022), and mortality (95%CI = 1.947-34.223, P = 0.004) in multivariate regression analysis. ROC analysis showed that thrombocytopenia may be an identified marker of shock [area under the ROC curve (AUC), 0.8119; cut-off, 92.50; P < 0.0001], ICU admission (AUC, 0.7484; cut-off, 82.50; P < 0.0015), and mortality (AUC, 0.7827; cut-off, 122.50; P < 0.002). These findings remained consistent across 86 pairs of patients analyzed for PSM analyses.
UNASSIGNED: Thrombocytopenia is an independent risk factor for poor prognosis in PLA and patients may be more prone to adverse outcomes.