PDF(Pubmed)
Abstract：
UNASSIGNED: The prevalence of pyogenic liver abscess (PLA) is increasing worldwide. However, evaluation on its economic burden is still lack.
UNASSIGNED: A retrospective study that included all patients identified PLA from 2017 to 2020 was conducted. Clinical information and hospital costs were collected through the electronic medical records. We evaluated the economic burden using disability-adjusted life years (DALYs). Differences in socioeconomic burdens between Klebsiella pneumoniae-caused liver abscesses (KPLA) and non-Klebsiella pneumoniae-caused liver abscesses (non-KPLA) were compared.
UNASSIGNED: We found 327 patients identified PLA in the study, including 146 with KPLA and 181 with non-KPLA. The demographic characteristics, median hospital stay, severity, and in-hospital mortality were similar between the two groups. The median total in-hospital cost was higher in the non-KPLA than in the KPLA group, although no statistical difference was found ($3607.2 vs $3424.6; P = 0.446). The median DALY loss was significantly higher in the KPLA than in the non-KPLA group [1.49 (0.97-2.30) vs 1.27 (0.87-1.89); P = 0.033)], and male patients presented a higher average DALY loss than female patients. KPLA had a substantially greater median indirect economic loss than the non-KPLA group [$1442.8 (915.9-17,221.5) vs $1232.5 (764.6-15,473.0); P = 0.028], and indirect economic loss exhibited a significant increase from 2017 to 2020 in patients with PLA. No differences were found in the socioeconomic burden between the two groups [$8019.6 (4200.3-21,832.1) vs $7436.4 (4023.2-19,063.9); P = 0.172].
UNASSIGNED: The economic burden of PLA is significant, particularly in patients with KP. Patients with KPLA experienced increased DALY loss and indirect economic loss than non-KPLA. PLA must be prioritized as the indirect economic burden rises annually.
UNASSIGNED: A retrospective study that included all patients identified PLA from 2017 to 2020 was conducted. Clinical information and hospital costs were collected through the electronic medical records. We evaluated the economic burden using disability-adjusted life years (DALYs). Differences in socioeconomic burdens between Klebsiella pneumoniae-caused liver abscesses (KPLA) and non-Klebsiella pneumoniae-caused liver abscesses (non-KPLA) were compared.
UNASSIGNED: We found 327 patients identified PLA in the study, including 146 with KPLA and 181 with non-KPLA. The demographic characteristics, median hospital stay, severity, and in-hospital mortality were similar between the two groups. The median total in-hospital cost was higher in the non-KPLA than in the KPLA group, although no statistical difference was found ($3607.2 vs $3424.6; P = 0.446). The median DALY loss was significantly higher in the KPLA than in the non-KPLA group [1.49 (0.97-2.30) vs 1.27 (0.87-1.89); P = 0.033)], and male patients presented a higher average DALY loss than female patients. KPLA had a substantially greater median indirect economic loss than the non-KPLA group [$1442.8 (915.9-17,221.5) vs $1232.5 (764.6-15,473.0); P = 0.028], and indirect economic loss exhibited a significant increase from 2017 to 2020 in patients with PLA. No differences were found in the socioeconomic burden between the two groups [$8019.6 (4200.3-21,832.1) vs $7436.4 (4023.2-19,063.9); P = 0.172].
UNASSIGNED: The economic burden of PLA is significant, particularly in patients with KP. Patients with KPLA experienced increased DALY loss and indirect economic loss than non-KPLA. PLA must be prioritized as the indirect economic burden rises annually.
摘要：
■化脓性肝脓肿（PLA）的患病率正在全球范围内增加。然而,对其经济负担的评价仍然不足。
■进行了一项回顾性研究，纳入了2017年至2020年确定为PLA的所有患者。通过电子病历收集临床信息和住院费用。我们使用残疾调整生命年(DALYs)评估经济负担。比较了肺炎克雷伯菌引起的肝脓肿（KPLA）和非肺炎克雷伯菌引起的肝脓肿（非KPLA）之间的社会经济负担差异。
■我们发现327名患者在研究中确定了PLA，其中146人与人民解放军，181人与非人民解放军。人口特征，住院天数中位数,严重程度,两组的住院死亡率相似.非KPLA的住院总费用中位数高于KPLA组，尽管没有发现统计学差异（$3607.2vs$3424.6；P=0.446）。KPLA组的中位DALY损失明显高于非KPLA组[1.49（0.97-2.30）比1.27（0.87-1.89）；P=0.033]，男性患者的平均DALY损失高于女性患者。KPLA的间接经济损失中位数远高于非KPLA组[$1442.8（915.9-17,221.5）vs$1232.5（764.6-15,473.0）；P=0.028]，从2017年到2020年，PLA患者的间接经济损失显着增加。两组之间的社会经济负担没有差异[$8019.6（4200.3-21,832.1）与$7436.4（4023.2-19,063.9）；P=0.172]。
■解放军的经济负担很重,特别是在KP患者中。KPLA患者的DALY损失和间接经济损失比非KPLA增加。随着间接经济负担逐年增加，必须优先考虑解放军。
■进行了一项回顾性研究，纳入了2017年至2020年确定为PLA的所有患者。通过电子病历收集临床信息和住院费用。我们使用残疾调整生命年(DALYs)评估经济负担。比较了肺炎克雷伯菌引起的肝脓肿（KPLA）和非肺炎克雷伯菌引起的肝脓肿（非KPLA）之间的社会经济负担差异。
■我们发现327名患者在研究中确定了PLA，其中146人与人民解放军，181人与非人民解放军。人口特征，住院天数中位数,严重程度,两组的住院死亡率相似.非KPLA的住院总费用中位数高于KPLA组，尽管没有发现统计学差异（$3607.2vs$3424.6；P=0.446）。KPLA组的中位DALY损失明显高于非KPLA组[1.49（0.97-2.30）比1.27（0.87-1.89）；P=0.033]，男性患者的平均DALY损失高于女性患者。KPLA的间接经济损失中位数远高于非KPLA组[$1442.8（915.9-17,221.5）vs$1232.5（764.6-15,473.0）；P=0.028]，从2017年到2020年，PLA患者的间接经济损失显着增加。两组之间的社会经济负担没有差异[$8019.6（4200.3-21,832.1）与$7436.4（4023.2-19,063.9）；P=0.172]。
■解放军的经济负担很重,特别是在KP患者中。KPLA患者的DALY损失和间接经济损失比非KPLA增加。随着间接经济负担逐年增加，必须优先考虑解放军。
