背景:2022年7月,世界卫生组织(WHO)宣布猴痘病毒(MPXV)为国际关注的突发公共卫生事件,由于该疾病在非洲以前流行的国家之外的前所未有的全球传播。
方法:对于本系统综述,作者搜索了“科学网”(WoS)数据库,它检索了关于MPXV的138篇文章,在2022年01月04日和2022年22月09日之间发布。这一时期见证了世卫组织确认的最大感染病例。使用70篇文章进行了深入分析,在排除与该主题不高度相关的论文之后。
结论:当前的综述展示了不同类型的MPXV鉴定分析,MPXV的传输,临床特征,针对MPXV的免疫反应,突变,和系统发育分析。它还可以识别具有高风险并发症的患者,并确定与MPXV相关的其他疾病。本文为疫苗或抗病毒药物的适当使用提供了建议,以控制与人类有关的爆发和预防策略。本研究讨论了有助于减少MPXV传播的重要意义和建议,并为即将进行的MPXV研究提供了途径。
BACKGROUND: In July 2022, the world health organization (WHO) announced the monkeypox virus (MPXV) as a public health emergency of international concern, due to the unprecedented global transmission of the disease beyond previously endemic countries in Africa.
METHODS: For this systematic review, the author searched the \"web of science\" (WoS) database, which retrieves 138 articles on MPXV, published between 01-04-2022 and 22-09-2022. This period witnessed the maximum cases of infection as confirmed by the WHO. Seventy articles were used for in-depth analysis, after excluding papers not highly relevant to the topic.
CONCLUSIONS: The current review demonstrates different types of MPXV identification analysis, transmission of MPXV, clinical features, immune responses against MPXV, the mutations, and phylogenetic analysis. It also identifies the patients with high-risk complications and determines the other diseases related to MPXV. This paper provides suggestions for the suitable usage of vaccines or antiviral drugs as a procedure to control the outbreak and preventive strategies related to the humans. This research discusses significant implications and recommendations to contribute in reducing the spread of MPXV and presents avenues for upcoming MPXV research.