PDF(Pubmed)
Abstract：
Monkeypox (MPX), an orthopoxviral disease endemic in Africa, is now a public health emergency of international concern (PHEIC) as declared by the World Health Organization in July 2023. Although it is generally mild, the overall case fatality rate was reported to be 3%, and the basic reproduction number (R0) is > 1 in men who have sex with men (MSM, i.e., Portugal (1.4), the United Kingdom (1.6), and Spain (1.8)). However, R0 is < 1 in other settings. In concordance with the smallpox virus, it is also expected to increase the risk of adverse outcomes for both the mother and the fetus. The outcomes of the disease in an immunocompromised state of pregnancy are scary, showing high mortality and morbidity of both mother and fetus, with up to a 75% risk of fetal side effects and a 25% risk of severe maternal diseases. Therefore, it warrants timely diagnosis and intervention. The reverse transcription polymerase chain reaction (RT PCR) test is the standard approach to diagnosis. We summarized the recent findings of MPX on pregnancy, and the associated risk factors. We also give recommendations for active fetal surveillance, perinatal care, and good reporting to improve outcomes. The available vaccines have shown promise for primary disease prevention.
摘要：
猴痘(MPX),一种非洲流行的正痘病毒病，现在是世界卫生组织于2023年7月宣布的国际关注的公共卫生紧急情况（PHEIC）。虽然一般是温和的，据报道，总病死率为3%，在与男性发生性关系的男性中，基本繁殖数(R0)>1(MSM，即，葡萄牙(1.4),联合王国（1.6），西班牙（1.8）。然而,在其他设置中，R0<1。与天花病毒一致，预计这也会增加母亲和胎儿出现不良后果的风险.这种疾病在免疫受损的妊娠状态下的结果是可怕的，显示母亲和胎儿的高死亡率和发病率，胎儿副作用的风险高达75%，严重孕产妇疾病的风险高达25%。因此,它需要及时诊断和干预。逆转录聚合酶链反应（RTPCR）测试是诊断的标准方法。我们总结了MPX对妊娠的最新发现，以及相关的危险因素。我们还给出了积极监测胎儿的建议，围产期保健,和良好的报告，以改善结果。可用的疫苗已显示出预防初级疾病的希望。
