■化脓性汗腺炎(HS)是一种与恶性肿瘤风险增加相关的慢性炎症性疾病。这项系统评价的目的是调查HS中不同恶性肿瘤的患病率。
■本审查符合PRISMA标准。采用数据驱动的方法进行研究,其中涉及详细的关键字搜索。这项研究考虑了荟萃分析,实验研究,病例对照研究,横断面研究,队列研究,最近公布的案例,以英语或德语出版。排除了评论,摘要,和给编辑的信,以及研究,这不是基于人口。
■在最初发现的443种出版物中,25符合本系统评价的纳入标准。HS患者患癌症的风险显著增加,高达50%。此外,口咽的风险,中枢神经系统,结直肠,前列腺,外阴和非黑色素细胞皮肤癌随着HS的严重程度而增加。与健康对照相比,HS患者共病淋巴瘤的可能性明显更高。在严重的HS病例中,腹股沟病变的恶性变性,肛周,会阴,和臀区可发生在高达4.6%的病例中。这导致了CSCC的发展,通常有一个复杂的过程,更难以治疗,并与较差的结果相关。导致HS恶性转化的致病机制目前尚不清楚。
■与普通人群相比,患有HS的患者患癌症的风险更高。未治疗,长期HS病变可导致复杂的恶性变性,导致皮肤鳞状细胞癌。这种恶性变性的潜在机制尚不完全清楚。HS患者患其他癌症的风险也增加,包括前列腺,口服,中枢神经系统的咽部和结肠直肠癌和淋巴瘤。
UNASSIGNED: Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with an increased risk of malignancy. The aim of this systematic review was to investigate the prevalence of different malignancies in HS.
UNASSIGNED: This review meets the PRISMA criteria. A data-driven approach was used to conduct the research, which involved a detailed keyword search. The study considered meta-analyses, experimental studies, case-control studies, cross-sectional studies, cohort studies, and recently published cases, published in English or German. Excluded were reviews, summaries, and letters to the editor, as well as studies, which are not based on the human population.
UNASSIGNED: Out of the initial 443 publications found, 25 met the inclusion criteria for this systematic review. Patients with HS have a significantly increased risk of cancer, up to 50%. Additionally, the risk of oropharyngeal, central nervous system, colorectal, prostate, vulvar and non-melanocytic skin cancers increase with the severity of HS. The likelihood of comorbid lymphoma in patients with HS is significantly higher compared to healthy controls. In severe cases of HS, malignant degeneration of lesions in the groin, perianal, perineal, and gluteal region can occur in up to 4.6% of cases. This leads to the development of cSCC, which often have a complicated course, are more refractory to treatment and associated with a poorer outcome. The pathogenic mechanisms responsible for the malignant transformation of HS are currently unknown.
UNASSIGNED: Patients with HS have a higher risk of cancer compared to the general population. Untreated, long-standing HS lesions can lead to complicated malignant degeneration resulting in cutaneous squamous cell carcinoma. The mechanisms underlying this malignant degeneration are not fully understood. HS patients also have an increased risk of developing other cancers, including prostate, oral, pharyngeal and colorectal cancers of the central nervous system and lymphomas.