Abstract：
In the 1970s, human papillomaviruses (HPV) were ascertained as the aetiologic agents of cervical carcinoma. Subsequently, an association with HPV was established in other epithelial tumours, including squamous cell carcinoma of the head and neck (HNSCC). HPV has demonstrated a high potential for inducing oropharyngeal tumours, with HPV-16 infection posing a significant oncogenic risk. People living with HIV (PLWH) are identified as being at a higher risk of HPV infection and the subsequent development of HPV-associated tumours of the oropharynx. We present two patients under the care of the Department of AIDS with long-term HIV infections who were newly diagnosed with HPV-associated carcinomas of the tonsils. Both patients had been on antiretroviral therapy (ART) for over 15 years, achieving optimal viral suppression for more than 10 years. Chemotherapy and radiation therapy were employed in the treatment of the carcinomas. Throughout the neoplastic disease treatment, both patients maintained optimal viral suppression for HIV. The presented cases underscore the fact that despite achieving long-term optimal viral suppression of HIV, people living with HIV remain susceptible to the development of HPV-associated neoplasms.
摘要：
在1970年代,人乳头瘤病毒(HPV)被确定为宫颈癌的致病因子.随后，在其他上皮肿瘤中建立了与HPV的关联，包括头颈部鳞状细胞癌（HNSCC）。HPV已经证明了诱导口咽肿瘤的高潜力，HPV-16感染构成显著的致癌风险。HIV感染者（PLWH）被认为具有较高的HPV感染风险，并随后发展为HPV相关的口咽肿瘤。我们介绍了两名在AIDS部门长期感染HIV的患者，他们新诊断出患有HPV相关的扁桃体癌。两名患者都接受了抗逆转录病毒治疗（ART）超过15年，实现最佳的病毒抑制超过10年。在癌症的治疗中采用化学疗法和放射疗法。在整个肿瘤性疾病治疗中，两名患者对HIV保持最佳的病毒抑制作用.这些病例强调了这样一个事实，即尽管实现了对HIV病毒的长期最佳抑制，HIV感染者仍易患HPV相关肿瘤.
