目的:探讨头颈部肿瘤放疗患者放射性口腔黏膜炎(RIOM)的危险因素。
方法:回顾性收集2015年4月1日至2019年4月1日在我院接受放化疗的头颈部肿瘤患者资料。根据是否发生RIOM,将他们分为发生率组(n=48)和非发生率组(n=76)。并收集相关数据进行比较。
结果:两组患者在肿瘤类型方面有统计学差异,吸烟百分比,教育水平百分比,肿瘤分期,口腔粘膜炎症阶段,放疗剂量,粘膜保护剂,和口腔卫生状况(P<0.05);回归分析结果显示吸烟(OR=1.274,95%CI:1.095-2.007),大剂量放疗(OR=1.223,95%CI:1.098-2.077),口腔卫生不良(OR=1.367,95%CI:1.024-2.890)是RIOM的危险因素。
结论:吸烟,大剂量放射治疗,口腔卫生不良是头颈部放化疗后发生RIOM的危险因素。
OBJECTIVE: To explore the risk factors of radiation-induced oral mucositis (RIOM) in patients with head and neck tumors undergoing radiotherapy.
METHODS: A retrospective collection was conducted on patients with head and neck tumors who underwent radiotherapy and chemotherapy in our hospital from April 1, 2015 to April 1, 2019. They were divided into an incidence group (n=48) and a non-incidence group (n=76) based on whether RIOM occurred, and relevant data was collected for comparison.
RESULTS: There were statistically significant differences between the two groups of patients in terms of tumor type, smoking percentage, education level percentage, tumor stage, oral mucosal inflammation stage, radiotherapy dose, mucosal protectants, and oral hygiene condition(P<0.05); The regression analysis results showed that smoking (OR=1.274, 95% CI: 1.095-2.007), high-dose radiotherapy (OR=1.223, 95% CI: 1.098-2.077), and poor oral hygiene (OR=1.367, 95% CI: 1.024-2.890) were risk factors for RIOM.
CONCLUSIONS: Smoking, high-dose radiotherapy, and poor oral hygiene were risk factors for RIOM in head and neck patients after radiotherapy and chemotherapy.