本系统综述旨在全面了解人乳头瘤病毒(HPV)在不明原发头颈癌(HNCUP)中的作用。HNCUP是一种罕见的癌症,原发部位未知,这使得诊断和治疗变得困难。该评论包括2013年至2023年之间发表的文章,这些文章调查了HNCUP中HPV的患病率,它与临床结果的关联,及其对诊断和治疗的潜在影响。在11个电子数据库中进行搜索,和灰色文献:科克伦,Cumed,IBECS,JAMA网络,LILACS,MEDLINEOvid,MEDLINE-EBSCO,PubMed,Scopus,SciELO,和Taylor&FrancisOnline;共有23项研究符合纳入标准。该综述发现,HPV存在于相当比例的HNCUP病例中,从15.5%到100%不等。HNCUP发病率在增加,在一些研究中,HPV的存在与改善的临床结果有关,如总生存期和无病生存期;但发现与其他结局无关.这可能对诊断和治疗策略有影响。这篇综述的结果表明,需要进一步的研究来更好地了解HPV在HNCUP中的作用,并开发针对这种疾病的靶向治疗方法。
This systematic
review aims to provide a comprehensive understanding of the role of human papillomavirus (HPV) in head and neck cancer of unknown primary (HNCUP). HNCUP is a rare type of cancer with an unknown primary site, which makes it difficult to diagnose and treat. The
review includes articles published between 2013 and 2023 that investigated the prevalence of HPV in HNCUP, its association with clinical outcomes, and its potential implications for diagnosis and treatment. The search was conducted in 11 electronic databases, and the gray literature: Cochrane, Cumed, IBECS, JAMA Network, LILACS, MEDLINE Ovid, MEDLINE-EBSCO, PubMed, Scopus, SciELO, and Taylor & Francis Online; a total of 23 studies met the inclusion criteria. The
review found that HPV is present in a significant proportion of HNCUP cases, ranging from 15.5% to 100%. HNCUP incidence is increasing, and the presence of HPV was associated with improved clinical outcomes in some studies, such as overall survival and disease-free survival; but was found to have no association with outcomes in others. This may have implications for diagnostic and treatment strategies. The findings of this
review suggest that further research is needed to better understand the role of HPV in HNCUP and to develop targeted therapies for this disease.