研究聚糖及其在体内的功能有助于理解疾病机制和开发新的治疗方法。这需要提供与其他科学领域(如基因组学)相关信息整合的全面聚糖数据的资源,遗传学,蛋白质组学,代谢组学,和化学。本文介绍了美国国家生物技术信息中心(NCBI)的两种资源,NCBIGlycans和PubChem,这为糖学研究界提供了与聚糖相关的信息。NCBIGlycans(https://www.ncbi.nlm.nih.gov/聚糖/)是NCBI糖生物学数据内容的专用网站,可快速访问散布在多个NCBI数据库以及NCBI外部的其他信息资源中的聚糖相关信息。重要的是,NCBIGlycans托管聚糖符号命名法(SNFG)的官方网页,这是推荐用于科学出版物的聚糖结构的标准图形表示。另一方面,PubChem(https://pubchem.ncbi.nlm.nih.gov)是一家专注于研究的公司,大型公共化学数据库,包含大量含聚糖的记录,并与重要的糖学资源如GlyTouCan整合,GlyCosmos,和GlyGen.PubChem在多个数据集合中组织聚糖相关信息(即,Substance,化合物,蛋白质,Gene,Pathway,和分类),并提供各种工具和服务,允许用户通过Web浏览器以交互方式访问它们,并通过REST-ful接口以编程方式访问它们,包括PUG-View。NCBIGlycans和PubChem突出显示了与聚糖相关的数据,并提高了它们的可访问性,帮助科学家在研究中利用这些数据。
Studying glycans and their functions in the body aids in the understanding of disease mechanisms and developing new treatments. This necessitates resources that provide comprehensive
glycan data integrated with relevant information from other scientific fields such as genomics, genetics, proteomics, metabolomics, and chemistry. The present paper describes two resources at the U.S. National Center for Biotechnology Information (NCBI), the NCBI Glycans and PubChem, which provide
glycan-related information useful for the glycoscience research community. The NCBI Glycans ( https://www.ncbi.nlm.nih.gov/glycans/ ) is a dedicated website for glycobiology data content at NCBI and provides quick access to glycan-related information scattered across multiple NCBI databases as well as other information resources external to NCBI. Importantly, the NCBI Glycans hosts the official web page for the symbol nomenclature for glycans (SNFG), which is the standard graphical representation of
glycan structures recommended for scientific publication. On the other hand, PubChem ( https://pubchem.ncbi.nlm.nih.gov ) is a research-focused, large-scale public chemical database, containing a substantial number of glycan-containing records and is integrated with important glycoscience resources like GlyTouCan, GlyCosmos, and GlyGen. PubChem organizes
glycan-related information within multiple data collections (i.e., Substance, Compound, Protein, Gene, Pathway, and Taxonomy) and provides various tools and services that allow users to access them both interactively through a web browser and programmatically through a REST-ful interface, including PUG-View. The NCBI Glycans and PubChem highlight
glycan-related data and improve their accessibility, helping scientists exploit these data in their research.