PDF(Pubmed)
Abstract：
Glycans play critical roles in the host-pathogen interactions leading to infection. However, we still understand very little about the dynamic nature of glycosylation in response to infection and its function in modulating host immunity. Many of the host proteins involved in immune defense are glycoproteins. Furthermore, the innate immune system recognizes glycans. The glycoform of a protein can impact proteolytic stability, receptor interactions, serum half-life, and other aspects. New, cutting-edge chemical biology tools are shedding light on the interplay between infection and the host glycome. In this review, we highlight new work on the importance of dynamic glycosylation of host proteins in the innate and adaptive immune pathways in response to infection. These include recent findings on altered glycoprofiles of mucins, complement components, and antibodies.
摘要：
聚糖在导致感染的宿主-病原体相互作用中起关键作用。然而,我们对糖基化对感染的反应及其在调节宿主免疫中的功能的动态性质仍然知之甚少。参与免疫防御的许多宿主蛋白是糖蛋白。此外，先天免疫系统识别聚糖。蛋白质的糖型可以影响蛋白水解稳定性，受体相互作用，血清半衰期,和其他方面。新,尖端的化学生物学工具正在阐明感染与宿主糖素之间的相互作用。在这次审查中,我们强调了新的研究,即宿主蛋白动态糖基化在先天和适应性免疫途径中对感染的反应的重要性.这些包括最近关于改变粘蛋白糖谱的发现，补体成分,和抗体。
