PDF(Pubmed)
Abstract：
Glycan-based scaffolds are unique in their high specificity, versatility, low immunogenicity, and ability to mimic natural carbohydrates, making them attractive candidates for use in cancer treatment. These scaffolds are made up of glycans, which are biopolymers with well biocompatibility in the human body that can be used for drug delivery. The versatility of glycan-based scaffolds allows for the modulation of drug activity and targeted delivery to specific cells or tissues, which increases the potency of drugs and reduces side effects. Despite their promise, there are still technical challenges in the design and production of glycan-based scaffolds, as well as limitations in their therapeutic efficacy and specificity.
摘要：
基于聚糖的支架在其高特异性方面是独特的，多功能性，低免疫原性,以及模仿天然碳水化合物的能力，使它们成为用于癌症治疗的有吸引力的候选人。这些支架是由聚糖组成的,它们是在人体中具有良好生物相容性的生物聚合物，可用于药物输送。基于聚糖的支架的多功能性允许调节药物活性和靶向递送至特定细胞或组织,这增加了药物的效力并减少了副作用。尽管他们的承诺，聚糖基支架的设计和生产仍然存在技术挑战，以及其治疗效果和特异性的局限性。
