微流体方法主要利用两种不相容的液体分别作为连续相和分散相。它通过管理微通道结构和两相的流速比来控制液滴的形成。基于液滴的微流体是一个迅速扩展的跨学科研究领域,涵盖物理学,生物化学,和微系统工程。与传统仪器相比,液滴微流体提供了多样化和实用的工具集,使化学和生物实验能够以更高的速度和更高的效率进行。基于液滴的微流体的应用是广泛的,包括药物输送等领域,由于其与众多化学和生物试剂的兼容性以及进行各种操作的能力。该技术由于其具有前景的特点而得到了广泛的研究。在这次审查中,我们深入研究了基于液滴生成的微流体设备中使用的材料,制造技术,在通道中产生液滴的方法,and,最后,我们总结了基于液滴生成的微流体在药物递送载体中的应用,包括纳米粒子,微球,微胶囊,和水凝胶颗粒。我们还讨论了该技术在各种应用中的挑战和未来前景。
The microfluidic method primainly utilizes two incompatible liquids as continuous phase and dispersed phase respectively. It controls the formation of droplets by managing the microchannel structure and the flow rate ratio of the two phases.
Droplet-based microfluidics is a rapidly expanding interdisciplinary research field encompassing physics, biochemistry, and Microsystems engineering.
Droplet microfluidics offer a diverse and practical toolset that enables chemical and biological experiments to be conducted at high speeds and with greater efficiency compared to traditional instruments. The applications of
droplet-based microfluidics are vast, including areas such as drug delivery, owing to its compatibility with numerous chemical and biological reagents and its ability to carry out various operations. This technology has been extensively researched due to its promising features. In this review, we delve into the materials used in droplet generation-based microfluidic devices, manufacturing techniques, methods for
droplet generation in channels, and, finally, we summarize the applications of
droplet generation-based microfluidics in drug delivery vectors, encompassing nanoparticles, microspheres, microcapsules, and hydrogel particles. We also discuss the challenges and future prospects of this technology across a wide array of applications.