目的:接受癌症治疗的患者经历了大量的皮肤,头发,和指甲不良事件,提示他们使用非循证且通常限制性的非处方(OTC)建议来缓解症状。全面评估基于证据的OTC模式对于使癌症患者能够舒适地恢复治疗后的生活并将临床上合理的实践融入他们的自我护理程序至关重要。
目的:对基于证据的非处方药皮肤进行系统评价和评估,头发,和成人癌症治疗患者的指甲护理建议。
方法:PubMed,科克伦,Embase,和Medline数据库在2023年3月进行了搜索,以识别针对OTC皮肤的英文文章,头发,和成人患者之前的指甲护理建议,during,以及癌症化疗或放疗(RT)后。根据牛津循证医学中心标准评估质量。
结果:筛选了2192篇独特文章,其中77项符合纳入标准,由54项随机对照试验(RCT)组成,8个非随机对照队列,1项非随机对照临床试验,3个对照前瞻性队列,4个前瞻性队列,2个对照临床试验,1个前瞻性比较研究,2例病例报告,和2例病例系列讨论9322例患者。在我们的数据库搜索之外的另一篇文章总共包含了78篇文章。具有最佳证据质量的OTC皮肤护理治疗包括保湿霜。我们的评论显示,缺乏基于证据的头发和指甲护理实践。
结论:本系统综述旨在强调多种OTC皮肤的功效,头发,和成人癌症患者的指甲护理建议,同时鼓励进一步的临床试验,以建立循证管理指南。
OBJECTIVE: Patients undergoing cancer treatment experience a multitude of skin, hair, and nail adverse events, prompting them to use non-evidence-based and often restrictive over-the-counter (OTC) recommendations to alleviate their symptoms. Comprehensively assessing evidence-based OTC modalities is crucial to enable cancer patients to comfortably resume their lives post-treatment and integrate clinically sound practices into their self-care routines.
OBJECTIVE: Perform a systematic review and assessment of evidence-based OTC skin, hair, and nail care recommendations for adult patients undergoing cancer treatment.
METHODS: PubMed, Cochrane, Embase, and Medline databases were searched in March 2023 to identify English articles addressing OTC skin, hair, and nail care recommendations for adult patients before, during, and after cancer chemotherapy or radiation therapy (RT). Quality was assessed with Oxford Centre for Evidence Based Medicine criteria.
RESULTS: 2192 unique articles were screened, of which 77 met inclusion criteria consisting of 54 randomized controlled trials (RCT), 8 non-randomized controlled cohorts, 1 non-randomized controlled clinical trial, 3 controlled prospective cohorts, 4 prospective cohorts, 2 controlled clinical trials, 1 prospective comparative study, 2 case reports, and 2 case series discussing 9322 patients. An additional article outside of our database search was included for a total of 78 articles. OTC skin care treatments with the best quality of evidence included moisturizing creams. Our review revealed a paucity of evidence-based hair and nail care practices.
CONCLUSIONS: This systematic review serves to highlight the efficacy of diverse OTC skin, hair, and nail care recommendations for adult cancer patients while encouraging further clinical trials to establish evidence-based management guidelines.