Abstract：
BACKGROUND: In the Nordic European Countries, cancer is the leading cause of death. The last decade has brought revolutionizing cancer treatments including immune checkpoint inhibitors (ICIs). Patients on ICIs have a high risk of developing cutaneous immune-related adverse events. Treating these side effects is of high importance to improve patient\'s quality of life (QoL) and continue the anti-cancer treatment.
METHODS: The Nordic European Cutaneous Oncodermatology Management (NECOM) project develops tools to prevent and treat cancer therapy-related cutaneous adverse events (cAEs). The first 2 NECOM papers presented various cAEs and skincare regimens involving hygiene, moisturization, sun protection, and camouflage products for preventing and managing cAEs. The NECOM 3 practical algorithm was on the prevention and treatment of acute radiation dermatitis. This NECOM 4 practical algorithm is intended to prevent and manage cutaneous immunotherapy-related adverse events (cirAEs), improving cancer patients\' QoL and outcomes.
RESULTS: The NECOM advisors discussed the results of a systematic literature review and obtained consensus on the evidence and expert opinion-based practical algorithm for cirAEs to support all healthcare providers treating cancer patients in the Nordic European Countries. The algorithm starts with a simple skincare regimen of cleansing, moisturizing, and protection, followed by the exclusion of severe cutaneous adverse reactions, and then specific interventions to treat the most common cirAEs (pruritus, maculopapular eruption, eczematous eruption, psoriasis, lichenoid eruption, and bullous eruption).
CONCLUSIONS: CirAEs are the most common side effects induced by ICIs and may lead to cancer treatment interruption or even discontinuation. Patient education on the prevention of cirAEs using a skincare regimen and treatment recommendations given in the NECOM 4 algorithm may help prevent and manage cirAEs and improve the QoL and outcome of patients receiving ICIs. J Drugs Dermatol. 2024;23:8(Suppl 2):s4-10.
METHODS: The Nordic European Cutaneous Oncodermatology Management (NECOM) project develops tools to prevent and treat cancer therapy-related cutaneous adverse events (cAEs). The first 2 NECOM papers presented various cAEs and skincare regimens involving hygiene, moisturization, sun protection, and camouflage products for preventing and managing cAEs. The NECOM 3 practical algorithm was on the prevention and treatment of acute radiation dermatitis. This NECOM 4 practical algorithm is intended to prevent and manage cutaneous immunotherapy-related adverse events (cirAEs), improving cancer patients\' QoL and outcomes.
RESULTS: The NECOM advisors discussed the results of a systematic literature review and obtained consensus on the evidence and expert opinion-based practical algorithm for cirAEs to support all healthcare providers treating cancer patients in the Nordic European Countries. The algorithm starts with a simple skincare regimen of cleansing, moisturizing, and protection, followed by the exclusion of severe cutaneous adverse reactions, and then specific interventions to treat the most common cirAEs (pruritus, maculopapular eruption, eczematous eruption, psoriasis, lichenoid eruption, and bullous eruption).
CONCLUSIONS: CirAEs are the most common side effects induced by ICIs and may lead to cancer treatment interruption or even discontinuation. Patient education on the prevention of cirAEs using a skincare regimen and treatment recommendations given in the NECOM 4 algorithm may help prevent and manage cirAEs and improve the QoL and outcome of patients receiving ICIs. J Drugs Dermatol. 2024;23:8(Suppl 2):s4-10.
摘要：
背景：在北欧国家，癌症是导致死亡的主要原因。过去十年带来了革命性的癌症治疗，包括免疫检查点抑制剂（ICIs）。ICIs患者发生皮肤免疫相关不良事件的风险很高。治疗这些副作用对于改善患者的生活质量（QoL）和继续抗癌治疗非常重要。
方法：北欧欧洲皮肤皮肤病学管理（NECOM）项目开发了预防和治疗癌症治疗相关皮肤不良事件（cAE）的工具。NECOM的前2篇论文介绍了涉及卫生的各种cAE和护肤方案，保湿，防晒,以及用于预防和管理cAE的伪装产品。NECOM一3实际算法对急性放射性皮炎的预防和医治停止了研讨。该NECOM4实用算法旨在预防和管理与皮肤免疫疗法相关的不良事件（CirAE），改善癌症患者的QoL和预后。
结果：NECOM顾问讨论了系统文献综述的结果，并就证据和基于专家意见的cirAE实用算法达成共识，以支持北欧国家所有治疗癌症患者的医疗保健提供者。该算法从一个简单的清洁护肤方案开始，保湿,和保护,随后排除严重的皮肤不良反应，然后是治疗最常见的cirAE的具体干预措施(瘙痒，斑丘疹,湿疹喷发，牛皮癣,苔藓样喷发,和大疱性喷发）。
结论：CirAE是ICIs引起的最常见的副作用，可能导致癌症治疗中断甚至中断。使用皮肤护理方案和NECOM4算法中给出的治疗建议对患者进行预防cirAE的教育可能有助于预防和管理cirAE，并改善接受ICI的患者的QoL和结果。J药物Dermatol.2024；23:8（增刊2）：4-10。
方法：北欧欧洲皮肤皮肤病学管理（NECOM）项目开发了预防和治疗癌症治疗相关皮肤不良事件（cAE）的工具。NECOM的前2篇论文介绍了涉及卫生的各种cAE和护肤方案，保湿，防晒,以及用于预防和管理cAE的伪装产品。NECOM一3实际算法对急性放射性皮炎的预防和医治停止了研讨。该NECOM4实用算法旨在预防和管理与皮肤免疫疗法相关的不良事件（CirAE），改善癌症患者的QoL和预后。
结果：NECOM顾问讨论了系统文献综述的结果，并就证据和基于专家意见的cirAE实用算法达成共识，以支持北欧国家所有治疗癌症患者的医疗保健提供者。该算法从一个简单的清洁护肤方案开始，保湿,和保护,随后排除严重的皮肤不良反应，然后是治疗最常见的cirAE的具体干预措施(瘙痒，斑丘疹,湿疹喷发，牛皮癣,苔藓样喷发,和大疱性喷发）。
结论：CirAE是ICIs引起的最常见的副作用，可能导致癌症治疗中断甚至中断。使用皮肤护理方案和NECOM4算法中给出的治疗建议对患者进行预防cirAE的教育可能有助于预防和管理cirAE，并改善接受ICI的患者的QoL和结果。J药物Dermatol.2024；23:8（增刊2）：4-10。
