目的:评估间歇性禁食的影响,有或没有益生菌补充剂,与人体测量的卡路里限制饮食相比,多囊卵巢综合征(PCOS)女性的代谢状态和性腺变量。
方法:这是一个随机的,安慰剂对照,平行臂临床试验。14:10早期限时进食(eTRE)策略单独或与益生菌联合使用的效果,患有PCOS的肥胖女性,被调查了。参与者分为三组:eTRE+益生菌(n=30),eTRE加安慰剂(n=30)和对照组,遵循标准的每日三餐饮食,每日热量限制(DCR)(n=30)。超过8周,各种人体测量学,新陈代谢,评估了月经和性腺变量。
结果:本研究共纳入90人,平均体重为81.4公斤,平均年龄30岁.在第8周,两组之间的平均(标准偏差)体重减轻没有差异(TRE+益生菌:-2.2[1.6]kgvs.TRE+安慰剂:-2.9[2.7]kgvs.DCR:-2.5[1.7]kg)。结果显示,虽然这三种方法都能减轻体重,身体质量指数,血管风险指标,多毛症和痤疮评分,eTRE组与对照组在体重减轻方面无统计学差异,或者新陈代谢的改善,月经和性腺变量(P>0.05)。此外,益生菌与eTRE联合使用对激素和心脏代谢因子没有益处(P>.05).
结论:单独的eTRE或eTRE加益生菌并没有导致明显更大的体重减轻或代谢改善,与标准三餐DCR饮食相比,月经和性腺变量。
OBJECTIVE: To assess the impact of intermittent fasting, with or without probiotic supplementation, versus a calorie-restricted diet on anthropometric measures, metabolic status and gonadal variables in women with polycystic ovary syndrome (PCOS).
METHODS: This is a randomized, placebo-controlled, parallel-arm clinical trial. The effects of the 14:10 early time-restricted eating (eTRE) strategy alone or combined with probiotics, on obese women with PCOS, were investigated. Participants were divided into three groups: eTRE plus probiotics (n = 30), eTRE plus placebo (n = 30) and a control group following a standard three-meal-per-day diet with daily calorie restriction (DCR) (n = 30). Over 8 weeks, various anthropometric, metabolic, menstrual and gonadal variables were assessed.
RESULTS: A total of 90 individuals were included in the study, with a mean body weight of 81.4 kg, and a mean age of 30 years. Mean (standard deviation) weight loss was not different between the groups at week 8 (TRE + probiotic: -2.2 [1.6] kg vs. TRE + placebo: -2.9 [2.7] kg vs. DCR: -2.5 [1.7] kg). Results revealed that, while all three regimes led to reductions in body weight, body mass index, vascular risk indicators, hirsutism and acne scores, there were no statistically significant differences between the eTRE groups and the control group in terms of weight loss, or improvements in metabolic, menstrual and gonadal variables (P > .05). Additionally, combining probiotics with eTRE did not benefit hormonal and cardiometabolic factors (P > .05).
CONCLUSIONS: The eTRE alone or eTRE plus probiotics did not result in significantly greater weight loss or improvements in metabolic, menstrual and gonadal variables compared with the standard three-meal DCR diet.